Interaction of high pressure and a narcotic dose of ethanol on spontaneous behavior in rats
| Autor: | Inmaculada Garcia-Cabrera, Odd-Geir Berge |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Myoclonus Atmosphere Exposure Chambers medicine.medical_specialty medicine.drug_class Narcotic medicine.medical_treatment Clinical Biochemistry Motor Activity Toxicology Helium Biochemistry Heliox Behavioral Neuroscience chemistry.chemical_compound Seizures Internal medicine Convulsion medicine Animals Toxicokinetics Biological Psychiatry Pharmacology Air Pressure Ethanol Chemistry Brain Rats Inbred Strains Hypothermia Rats Endocrinology High pressure Anesthesia Depressant medicine.symptom |
| Zdroj: | Pharmacology Biochemistry and Behavior. 37:577-581 |
| ISSN: | 0091-3057 |
| Popis: | This study analyses the spontaneous motor activity of rats that had received a narcotic dose of ethanol (3.5 g/kg) and were then exposed to 1 atmosphere absolute pressure (ATA) air or to 1 or 72 ATA of helium-oxygen (heliox). The ambient temperature was adjusted to offset ethanol- and helium-induced hypothermia. Ethanol administration prevented the occurrence of convulsions but did not alter the total number of myoclonic jerks at stable pressure. The ethanol-intoxicated animals exposed to high pressure did not exhibit normal locomotion but showed a trend towards increased activity during the last observation period. Similar blood and brain concentrations of ethanol were found in the 1 and 72 ATA groups. These results show that exposure to 72 ATA for 40 min started to exert some antagonistic effects, and they suggest that exposure to higher pressures or for a longer period of time may be sufficient to significantly offset the depressant effects of a narcotic dose of ethanol on spontaneous behavior in rats. At the same time, ethanol seems to protect against some aversive effects of high pressure. |
| Databáze: | OpenAIRE |
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