Antimicrobial effects of a macrophage-derived cytotoxin from the serum of BCG-primed rabbits (tumour necrosis serum)
| Autor: | Neale Ml, Matthews N |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Microbiology (medical)
Necrosis Gram-Positive Bacteria medicine.disease_cause Microbiology Cell Line Mice Neoplasms Candida albicans Gram-Negative Bacteria medicine Animals Macrophage Cytotoxicity Glycoproteins biology Cytotoxins Tumor Necrosis Factor-alpha Toxin Macrophages Biological activity General Medicine biology.organism_classification Antimicrobial Growth Inhibitors Immunology BCG Vaccine Protozoa Rabbits medicine.symptom |
| Zdroj: | Journal of Medical Microbiology. 17:211-213 |
| ISSN: | 1473-5644 0022-2615 |
| DOI: | 10.1099/00222615-17-2-211 |
| Popis: | SUMMARY. Previous studies have shown that a macrophage-derived cytotoxin, found in high titre in the serum of BCG-primed rabbits, killed malarial parasites and certain tumour cells. In this study, the macrophage cytotoxin was tested for activity against microorganisms other than protozoa. No activity was seen against a range of gram-negative or gram-positive bacteria or against Candida albicans. It is concluded that the macrophage cytotoxin has limited anti-microbial activity, perhaps restricted to certain intra-cellular parasites. |
| Databáze: | OpenAIRE |
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