Breast cancer survivors’ typhoid vaccine responses: Chemotherapy, obesity, and fitness make a difference

Autor:	Janice K. Kiecolt-Glaser, Megan Renna, Juan Peng, John Sheridan, Maryam Lustberg, Bhuvaneswari Ramaswamy, Robert Wesolowski, Jeffrey B. VanDeusen, Nicole O. Williams, Sagar D. Sardesai, Anne M. Noonan, Raquel E. Reinbolt, Daniel G. Stover, Mathew A. Cherian, William B. Malarkey, Rebecca Andridge
Rok vydání:	2022
Předmět:	Interleukin 1 Receptor Antagonist Protein Behavioral Neuroscience Cancer Survivors Interleukin-6 Endocrine and Autonomic Systems Obesity Abdominal Typhoid-Paratyphoid Vaccines Immunology Humans Breast Neoplasms Female Obesity Article
Zdroj:	Brain Behav Immun
ISSN:	0889-1591
DOI:	10.1016/j.bbi.2022.03.019
Popis:	PURPOSE: To investigate breast cancer survivors’ inflammatory responses to typhoid vaccine as a window into their innate immune response to novel pathogens. METHODS: This double-blind crossover trial randomized 158 breast cancer survivors to either the vaccine/saline placebo or the placebo/vaccine sequence. The relative contributions of age, cardiorespiratory fitness (VO(2peak)), type of cancer treatment, central obesity, and depression to interleukin (IL)-6, IL-1 receptor antagonist (IL-1Ra), and WBC vaccine responses were assessed pre-injection and 1.5, 3, 4.5, 6, and 7.5 hours post-injection. RESULTS: The vaccine produced larger IL-6, IL-1Ra, and WBC responses than placebo, ps
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965ecfd57c47492bb0b8612acf93cf3b https://doi.org/10.1016/j.bbi.2022.03.019 Zobrazit plný text záznamu Full Text from ScienceDirect