Characterization of prostate cancer using T2 mapping at 3T: A multi-scanner study
| Autor: | A. Hoang Dinh, Christelle Melodelima, Rémi Souchon, Olivier Rouvière, Flavie Bratan, Marc Colombel, Florence Mège-Lechevallier |
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| Jazyk: | angličtina |
| Předmět: |
Male
Scanner medicine.medical_specialty T2 mapping medicine.medical_treatment Normal tissue Malignancy Prostate cancer Predictive Value of Tests Prostate medicine Humans Radiology Nuclear Medicine and imaging Prostate multiparametric MRI Aged Retrospective Studies T2 Radiological and Ultrasound Technology Prostatectomy business.industry Prostatic Neoplasms General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging T2 value medicine.anatomical_structure Prostate cancer aggressiveness Radiology business |
| Zdroj: | Diagnostic and Interventional Imaging. (4):365-372 |
| ISSN: | 2211-5684 |
| DOI: | 10.1016/j.diii.2014.11.016 |
| Popis: | Rationale and objectives To assess the prostate T2 value as a predictor of malignancy on two different 3 T scanners. Patients and methods Eighty-three pre-prostatectomy multiparametric MRIs were retrospectively evaluated [67 obtained on a General Electric MRI (scanner 1) and 16 on a Philips MRI (scanner 2)]. After correlation with prostatectomy specimens, readers measured the T2 value of regions-of-interest categorized as “cancers”, “false positive lesions”, or “normal tissue”. Results On scanner 1, in PZ, cancers had significantly lower T2 values than false positive lesions ( P = 0.02) and normal tissue ( P = 2 × 10 −9 ). Gleason ≥ 6 cancers had similar T2 values than false positive lesions and significantly higher T2 values than Gleason ≥ 7 cancers ( P = 0.009). T2 values corresponding to a 25% and 75% risk of Gleason ≥ 7 malignancy were respectively 132 ms (95% CI: 129–135 ms) and 77 ms (95% CI: 74–81 ms). In TZ, cancers had significantly lower T2 values than normal tissue ( P = 0.008), but not than false positive findings. Mean T2 values measured on scanner 2 were not significantly different than those measured on scanner 1 for all tissue classes. Conclusion All tested tissue classes had similar mean T2 values on both scanners. In PZ, the T2 value was a significant predictor of Gleason ≥ 7 cancers. |
| Databáze: | OpenAIRE |
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