High-dose methotrexate: on the relationship of methotrexate elimination time vs renal function and serum methotrexate levels in 1164 courses in 264 Swedish children with acute lymphoblastic leukaemia (ALL)
| Autor: | Erik Forestier, Peter Höglund, Peter Jönsson, M Behrentz, Marianne Jarfelt, Lars Hjorth, Gudmar Lönnerholm, O. Bjork, Tor Skärby |
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| Rok vydání: | 2002 |
| Předmět: |
musculoskeletal diseases
Male Cancer Research medicine.medical_specialty Time Factors Urinalysis Adolescent medicine.drug_class Metabolic Clearance Rate medicine.medical_treatment Renal function Toxicology Kidney Kidney Function Tests Antimetabolite Gastroenterology chemistry.chemical_compound immune system diseases Internal medicine Acute lymphocytic leukemia medicine Humans heterocyclic compounds Pharmacology (medical) skin and connective tissue diseases Child Pharmacology Creatinine Chemotherapy medicine.diagnostic_test business.industry Infant Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Endocrinology Methotrexate Oncology chemistry Child Preschool Antifolate Female business medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0344-5704 |
| Popis: | The objectives of the present study were to determine the relationship between methotrexate (MTX) elimination time and various aspects of renal function and to evaluate the prognostic value of elevated serum MTX and creatinine for delayed MTX elimination.The majority of the 264 children were being treated for ALL. According to the NOPHO-92 protocol, 5 or 8 g MTX/m(2) was administered over 24 h. Serum creatinine was assessed daily. In 11 patients from one centre, renal function was studied in more detail using serum cystatin C, iohexol clearance, and urinary albumin, IgG and protein HC.Increased serum creatinine correlated significantly with the elimination time of MTX, whereas no indications were found of tubular or barrier function damage. Of the 1164 courses, 44 had delayed elimination of MTX (/=120 h). Serum MTX150 microM at the end of infusion had a sensitivity of 0.27 and a specificity of 0.94 to predict delayed MTX elimination, and/=50% increase in serum creatinine during the first treatment day (creatinine ratio) had a sensitivity of 0.32 and a specificity of 0.99. The corresponding risk ratios were 5 and 19 for MTX150 micro M and creatinine ratio, respectively. In courses with a normal elimination time (72 h), 99% of the courses had a rise in serum creatinine of less than 50%.Elevation of serum creatinine by more than 50% is a better predictor of delayed elimination than the level of serum MTX at the end of MTX infusion, especially if information on previous creatinine measurements is used to reduce the impact of an occasionally low serum creatinine value before the start of the MTX infusion. |
| Databáze: | OpenAIRE |
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