Mice deficient in microtubule-associated protein MAP1B show a distinct behavioral phenotype and altered retina function
| Autor: | Herbert Reitsamer, Susanne Pangratz-Fuehrer, Hermann Bubna-Littitz, Friedrich Propst |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Morris water navigation task Stimulation Water maze Motor Activity Biology Retina Open field Mice Behavioral Neuroscience Stress Physiological Electroretinography medicine Animals Maze Learning Vision Ocular Mice Knockout medicine.diagnostic_test Homozygote Phenotype Mice Inbred C57BL Electrophysiology medicine.anatomical_structure Exploratory Behavior Physical Endurance Female Microtubule-Associated Proteins Neuroscience Photic Stimulation |
| Zdroj: | Behavioural Brain Research. 164:188-196 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2005.06.018 |
| Popis: | We investigated mice deficient for the microtubule-associated protein MAP1B, a cytoskeletal element highly expressed in the developing nervous system, for altered performance in behavior, learning, and memory. Using the multiple T-maze, the open field and the Morris water maze we found that mice homozygous for a deletion of the MAP1B gene demonstrate impaired locomotor activity most likely correlated to a lack of physical endurance in general. In contrast, there were no significant differences in cognitive function and memory retention. In addition, we performed electroretinography and observed a reduction of the a-wave amplitude in response to single flash, white light stimulation. Taken together, these data provide further evidence for an important role of MAP1B in synaptic neurotransmission. |
| Databáze: | OpenAIRE |
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