Fibroblastic reticular cells guide T lymphocyte entry into and migration within the splenic T cell zone
| Autor: | Marc Bajénoff, Ronald N. Germain, Nicolas Glaichenhaus |
|---|---|
| Přispěvatelé: | Lymphocyte Biology Section ( NIAID ), National Institutes of Health, Immunologie des Maladies Infectieuses Allergiques et Autoimmunes, Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Lymphocyte Biology Section (NIAID), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Pathology
MESH: Spleen MESH: Mice Mutant Strains Lymphocyte MESH: Chemotaxis Leukocyte MESH : Arterioles MESH: T-Lymphocyte Subsets MESH : Radiation Chimera 0302 clinical medicine Reticular cell Immunology and Allergy Cytotoxic T cell MESH: Microscopy Confocal [ SDV.IMM ] Life Sciences [q-bio]/Immunology MESH: Animals MESH : Chemokine CCL21 0303 health sciences MESH : Adoptive Transfer MESH : Chemotaxis Leukocyte Marginal zone Cell biology medicine.anatomical_structure [SDV.IMM]Life Sciences [q-bio]/Immunology Lymph MESH: B-Lymphocyte Subsets MESH : Spleen medicine.medical_specialty MESH: Radiation Chimera T cell Immunology MESH : Mice Inbred C57BL Biology 03 medical and health sciences MESH: Arterioles MESH: Mice Inbred C57BL MESH : Fibroblasts MESH : Mice medicine MESH : Microscopy Confocal MESH: Mice 030304 developmental biology MESH: Chemokine CCL21 T lymphocyte MESH : T-Lymphocyte Subsets MESH : Mice Mutant Strains MESH: Adoptive Transfer MESH: Fibroblasts MESH : Stromal Cells MESH : Animals MESH: Stromal Cells Periarteriolar lymphoid sheaths 030215 immunology MESH : B-Lymphocyte Subsets |
| Zdroj: | Journal of Immunology Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2008, 181 (6), pp.3947-54 |
| ISSN: | 0022-1767 1550-6606 |
| Popis: | Although a great deal is known about T cell entry into lymph nodes, much less is understood about how T lymphocytes access the splenic white pulp (WP). We show in this study that, as recently described for lymph nodes, fibroblastic reticular cells (FRCs) form a network in the T cell zone (periarteriolar lymphoid sheath, PALS) of the WP on which T lymphocytes migrate. This network connects the PALS to the marginal zone (MZ), which is the initial site of lymphocyte entry from the blood. T cells do not enter the WP at random locations but instead traffic to that site using the FRC-rich MZ bridging channels (MZBCs). These data reveal that FRCs form a substrate for T cells in the spleen, guiding these lymphocytes from their site of entry in the MZ into the PALS, within which they continue to move on the same network. |
| Databáze: | OpenAIRE |
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