Hepatic Steatosis in Patients With Single Ventricle and a Fontan Circulation

Autor: Jonathan R. Dillman, Adam M. Lubert, Andrew T. Trout, Joseph J. Palermo, Alexander R. Opotowsky, Adam W. Powell, David A. Katz, Gruschen R. Veldtman, Mathias Possner, Daniel Peck, Tarek Alsaied, Nadeem Anwar, Faizeen Zafar, Stavra A. Xanthakos
Rok vydání: 2021
Předmět:
nonalcoholic fatty liver disease
Male
Fontan associated liver disease
obesity
030204 cardiovascular system & hematology
Fontan Procedure
Chronic liver disease
Pediatrics
Gastroenterology
Liver disease
Postoperative Complications
0302 clinical medicine
Nonalcoholic fatty liver disease
Prevalence
030212 general & internal medicine
Child
Original Research
hepatic steatosis
Congenital Heart Disease
Middle Aged
Prognosis
Magnetic Resonance Imaging
medicine.anatomical_structure
Liver
Echocardiography
Female
Cardiology and Cardiovascular Medicine
Adult
Heart Defects
Congenital

medicine.medical_specialty
Adolescent
Heart Ventricles
Fontan operation
Fontan circulation
Young Adult
03 medical and health sciences
Internal medicine
adult congenital heart disease
medicine
Humans
In patient
Ohio
Retrospective Studies
business.industry
abdominal fat
medicine.disease
Obesity
Fatty Liver
Ventricle
Steatosis
business
Follow-Up Studies
Zdroj: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
ISSN: 2047-9980
DOI: 10.1161/jaha.120.019942
Popis: Background Hepatic steatosis, caused by nonalcoholic fatty liver disease, is a leading cause of chronic liver disease. The interplay between hepatic steatosis and the development of liver disease following the Fontan procedure is not well understood. This study examined the prevalence and associations of hepatic steatosis in patients with a Fontan circulation. Methods and Results This was a single‐center retrospective study of 95 patients with a Fontan circulation with liver magnetic resonance imaging performed between 2012 and 2019. The average age at magnetic resonance imaging was 21.5±8.5 years. The percent liver fat signal was determined using magnetic resonance chemical shift‐encoded proton density fat fraction imaging. Hepatic steatosis was defined as liver fat ≥5% and was present in 10.5% of the cohort. The presence of hepatic steatosis was associated with higher body mass index (29±4 versus 24±6 kg/m 2 , P =0.006), a higher frequency of obesity (50% versus 12%, P =0.015), lower high‐density lipoprotein cholesterol (35±9 versus 43±14 mg/dL, P =0.050), and greater subcutaneous fat thickness (2.6±0.7 versus 1.8±1.0 cm, P =0.043). There was no association between hepatic steatosis and cardiovascular imaging or hemodynamic variables from cardiac catheterization. Conclusions Risk factors for hepatic steatosis in patients with Fontan circulation include obesity and dyslipidemia, similar to what is seen in the general population. Fontan hemodynamics were not associated with hepatic steatosis.
Databáze: OpenAIRE