Hepatic Steatosis in Patients With Single Ventricle and a Fontan Circulation
Autor: | Jonathan R. Dillman, Adam M. Lubert, Andrew T. Trout, Joseph J. Palermo, Alexander R. Opotowsky, Adam W. Powell, David A. Katz, Gruschen R. Veldtman, Mathias Possner, Daniel Peck, Tarek Alsaied, Nadeem Anwar, Faizeen Zafar, Stavra A. Xanthakos |
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Rok vydání: | 2021 |
Předmět: |
nonalcoholic fatty liver disease
Male Fontan associated liver disease obesity 030204 cardiovascular system & hematology Fontan Procedure Chronic liver disease Pediatrics Gastroenterology Liver disease Postoperative Complications 0302 clinical medicine Nonalcoholic fatty liver disease Prevalence 030212 general & internal medicine Child Original Research hepatic steatosis Congenital Heart Disease Middle Aged Prognosis Magnetic Resonance Imaging medicine.anatomical_structure Liver Echocardiography Female Cardiology and Cardiovascular Medicine Adult Heart Defects Congenital medicine.medical_specialty Adolescent Heart Ventricles Fontan operation Fontan circulation Young Adult 03 medical and health sciences Internal medicine adult congenital heart disease medicine Humans In patient Ohio Retrospective Studies business.industry abdominal fat medicine.disease Obesity Fatty Liver Ventricle Steatosis business Follow-Up Studies |
Zdroj: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
ISSN: | 2047-9980 |
DOI: | 10.1161/jaha.120.019942 |
Popis: | Background Hepatic steatosis, caused by nonalcoholic fatty liver disease, is a leading cause of chronic liver disease. The interplay between hepatic steatosis and the development of liver disease following the Fontan procedure is not well understood. This study examined the prevalence and associations of hepatic steatosis in patients with a Fontan circulation. Methods and Results This was a single‐center retrospective study of 95 patients with a Fontan circulation with liver magnetic resonance imaging performed between 2012 and 2019. The average age at magnetic resonance imaging was 21.5±8.5 years. The percent liver fat signal was determined using magnetic resonance chemical shift‐encoded proton density fat fraction imaging. Hepatic steatosis was defined as liver fat ≥5% and was present in 10.5% of the cohort. The presence of hepatic steatosis was associated with higher body mass index (29±4 versus 24±6 kg/m 2 , P =0.006), a higher frequency of obesity (50% versus 12%, P =0.015), lower high‐density lipoprotein cholesterol (35±9 versus 43±14 mg/dL, P =0.050), and greater subcutaneous fat thickness (2.6±0.7 versus 1.8±1.0 cm, P =0.043). There was no association between hepatic steatosis and cardiovascular imaging or hemodynamic variables from cardiac catheterization. Conclusions Risk factors for hepatic steatosis in patients with Fontan circulation include obesity and dyslipidemia, similar to what is seen in the general population. Fontan hemodynamics were not associated with hepatic steatosis. |
Databáze: | OpenAIRE |
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