Immunopathogenesis and immunotherapeutic approaches in multiple sclerosis
| Autor: | Gavin Giovannoni, E T Lim |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Autoimmune disease
Mitoxantrone Multiple Sclerosis business.industry General Neuroscience Multiple sclerosis medicine.medical_treatment Inflammation Immunotherapy Interferon-beta medicine.disease Immunology medicine Humans Pharmacology (medical) Neurology (clinical) Glatiramer acetate medicine.symptom β interferon business medicine.drug |
| Zdroj: | Expert review of neurotherapeutics. 5(3) |
| ISSN: | 1744-8360 |
| Popis: | Multiple sclerosis is an organ-specific autoimmune disease, characterized pathologically by cell-mediated inflammation, demyelination and variable degrees of axonal loss. Although inflammation is considered central to the pathogenesis of multiple sclerosis, to date, the only licensed and hence widely used multiple sclerosis immunotherapies are interferon-beta, glatiramer acetate and mitoxantrone. This review discusses the immunopathogenesis of multiple sclerosis, focusing on a number of emerging immunotherapies. A number of new approaches likely to manipulate the immunopathogenesis of multiple sclerosis and which may ultimately allow for the development of more effective immunotherapy are also highlighted. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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