Morphological, phytochemical and anti-hyperglycemic evaluation of Brachychiton populneus
| Autor: | S. A. M. Mosharrafa, Moshera M. El-Sherei, Mona M. Marzouk, Nabiel A.M. Saleh, Alia Y. Ragheb, Mona E.S. Kassem |
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| Rok vydání: | 2019 |
| Předmět: |
Anti-hyperglycemic activity
lcsh:RS1-441 Biology Chemosystematics 01 natural sciences Anti hyperglycemic lcsh:Pharmacy and materia medica chemistry.chemical_compound food Alloxan Male rats Micromorphology General Pharmacology Toxicology and Pharmaceutics Brachychiton populneus Malvaceae Flavonoids Traditional medicine 010405 organic chemistry biology.organism_classification food.food 0104 chemical sciences 010404 medicinal & biomolecular chemistry Brachychiton Phytochemical chemistry Macromorphology |
| Zdroj: | Revista Brasileira de Farmacognosia v.29 n.5 2019 Revista Brasileira de Farmacognosia Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA Revista Brasileira de Farmacognosia, Volume: 29, Issue: 5, Pages: 559-569, Published: 09 DEC 2019 Revista Brasileira de Farmacognosia, Vol 29, Iss 5, Pp 559-569 (2019) |
| ISSN: | 0102-695X |
| DOI: | 10.1016/j.bjp.2019.05.001 |
| Popis: | Brachychiton populneus (Schott & Endl.) R.Br., Malvaceae, is one of five Brachychiton species cultivated in Egypt. Little information was found concerning the morphological, phytochemical and biological investigations of B. populneus. Morphological investigations of B. populneus were performed on fresh and dried leaves. Air-dried, ground leafy branches were extracted with 70% methanol/water yielding B. populneus extract. Seventeen flavonoids were isolated and identified using different chromatographic and spectroscopic techniques; eleven of them were reported for the first time from this plant. Potential activity of B. populneus extract against alloxan inducing oxidative stress and diabetes in male rats was preliminary investigated (four groups of ten rats /group). B. populneus extract (500 mg/kg bw i.p.) exhibited significant acute anti-hyperglycemic activity with blood glucose levels of 227.3 and 157.6 mg/dl after 4 and 24 h, respectively, compared to alloxan and standard Diamicron (5 mg/kg bw p.o.) groups, as well as to a normoglycemic control group at p |
| Databáze: | OpenAIRE |
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