Successful treatment of non-familial haemophagocytic lymphohistiocytosis with interferon and gammaglobulin
| Autor: | R. D. Palmer, A. D. J. Pearson, E. J. Estlin, K. P. Windebank, M. F. Lowry |
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| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Cytotoxicity
Immunologic endocrine system Herpesvirus 4 Human Histiocytosis Non-Langerhans-Cell Alpha interferon Immunoglobulin E Virus Interferon hemic and lymphatic diseases Diseases in Twins Medicine Humans Interferon alfa biology business.industry Immunization Passive Infant Interferon-alpha Gamma globulin Herpesviridae Infections medicine.disease Killer Cells Natural Histiocytosis Tumor Virus Infections Pediatrics Perinatology and Child Health Immunology biology.protein Female Antibody business medicine.drug Research Article |
| Popis: | Two cases of non-familial haemophagocytic lymphohistiocytosis (HLH) are presented in which treatment with interferon alfa and gammaglobulin was associated with complete clinical remission. In one case, serological evidence of recent Epstein-Barr virus infection was found. Natural killer cell activity was within normal limits in both children, compatible with a secondary form of HLH. The combination of interferon alfa and intravenous gammaglobulin requires further evaluation in the treatment of non-familial HLH. |
| Databáze: | OpenAIRE |
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