Preclinical evaluation of nephroprotective potential of a probiotic formulation LOBUN on Cyclosporine-A induced renal dysfunction in Wistar rats
| Autor: | Thumati Nagendra Bhaskar Babu, Singirisetty Triveni, Kambham Venkateswarlu, Chilamakuru Naresh Babu, Thakur Heerasingh, Suroju Manasa |
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| Rok vydání: | 2017 |
| Předmět: |
LOBUN/effects/evaluation
medicine.medical_specialty Nephroprotective activity 030232 urology & nephrology lcsh:RS1-441 Urine Pharmacology urologic and male genital diseases Urine sodium law.invention lcsh:Pharmacy and materia medica 03 medical and health sciences chemistry.chemical_compound Probiotic 0302 clinical medicine Oral administration law Internal medicine Total serum protein medicine 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics Creatinine business.industry Probiotics Cyclosporine-A Serum uric acid medicine.disease LOBUN/effects Prebiotics Endocrinology chemistry Chronic Kidney Disease/study business Kidney disease |
| Zdroj: | Brazilian Journal of Pharmaceutical Sciences, Vol 53, Iss 2 (2017) Brazilian Journal of Pharmaceutical Sciences, Volume: 53, Issue: 2, Article number: e16041, Published: 22 JUN 2017 Brazilian Journal of Pharmaceutical Sciences; Vol. 53 No. 2 (2017); e16041 Brazilian Journal of Pharmaceutical Sciences; Vol. 53 Núm. 2 (2017); e16041 Brazilian Journal of Pharmaceutical Sciences; v. 53 n. 2 (2017); e16041 Brazilian Journal of Pharmaceutical Sciences Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1984-8250 2175-9790 |
| DOI: | 10.1590/s2175-97902017000216041 |
| Popis: | The aim of present study was to evaluate the nephroprotective effect of probiotic formulation LOBUN on Cyclosporine A (CsA) induced renal dysfunction in Wistar rats. CsA (20 mg/kg body weight s.c) was administered for 15 days to cause renal dysfunction in Wistar rats. The probiotic formulation LOBUN was administered with the dose of 500 mg/kg body weight (p.o) for twice (TGI) and thrice a day (TGII). The samples were analyzed for the parameters like blood urine nitrogen (BUN), serum creatinine, serum uric acid, total serum protein and urine proteins, urine potassium, urine sodium. The renal functional and histopathological studies revealed that the oral administration of probiotic formulation LOBUN has provided appreciable renoprotection and possibly alleviated the symptoms of Chronic Kidney Disease (CKD) at the dose of 500 mg/kg body weight administered thrice a day and also the results were supported by histopathological findings. |
| Databáze: | OpenAIRE |
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