Cyclocarioside O-Q, three novel seco-dammarane triterpenoid glycosides from the leaves of Cyclocarya paliurus
| Autor: | Gang-Zhi Zhu, Ze-Qun Nie, Zi-Jun Ye, Jie Tan, Wen-Yan Lv, Can Yang, Kang-Ping Xu, Ji-Hua Zhang, Hui-Hui Sun, Ke-Qing Zhang, Tong-Yao Xuan, Xiao-Ai He |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
biology 010405 organic chemistry Chemistry Organic Chemistry Dammarane Glycoside Plant Science biology.organism_classification medicine.disease 01 natural sciences Biochemistry Molecular biology 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Paliurus Triterpenoid Cell culture Pancreatic tumor Hepatocellular carcinoma medicine Cyclocarya |
| DOI: | 10.6084/m9.figshare.8276234 |
| Popis: | Three previously undescribed seco-dammarane triterpenoid glycosides O-Q (1-3) along with two known compounds (4 and 5) were isolated and characterized from the leaves of Cyclocarya paliurus. Their structures were determined by comprehensive analysis of 1 D, 2 D NMR and HRESIMS data. Compounds 1-5 were evaluated for their inhibitory effects against human pancreatic tumor (ASPC-1), human gastric carcinoma (SNU5), liver hepatocellular carcinoma (HEPG-2) and human colon tumor (HCT116) cell lines. Among them cyclocarioside P (2) showed somewhat inhibitory activity towards those tumor cells. |
| Databáze: | OpenAIRE |
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