The Incidence and Associated Factors of Early Neurological Deterioration After Thrombolysis
| Autor: | Wai M. Yu, Azmil H. Abdul-Rahim, Alan C. Cameron, Janika Kõrv, Petr Sevcik, Danilo Toni, Kennedy R. Lees, N. Wahlgren, N. Ahmed, V. Caso, C. Roffe, A. Kobayashi, G. Tsivgoulis, D. Toni, G.A. Ford, K.R. Lees, P. Ringleb |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty incidence multivariate analysis registries stroke tissue-type plasminogen activator medicine.medical_treatment Brain Ischemia Stroke onset Disability Evaluation Fibrinolytic Agents Predictive Value of Tests Risk Factors medicine Humans Thrombolytic Therapy Aged Retrospective Studies Aged 80 and over Advanced and Specialized Nursing business.industry Incidence (epidemiology) Thrombolysis Middle Aged Treatment Outcome Ischemic Attack Transient Tissue Plasminogen Activator Female Neurology (clinical) Nervous System Diseases Cardiology and Cardiovascular Medicine business |
| Zdroj: | Stroke. 51:2705-2714 |
| ISSN: | 1524-4628 0039-2499 |
| Popis: | Background and purpose: Early neurological deterioration (END) after stroke onset may predict severe outcomes. Estimated rates of END after intravenous thrombolysis among small patient samples have been reported up to 29.8%. We studied the incidence and factors associated with END among patients following intravenous thrombolysis. Methods: We analyzed SITS-International Stroke Thrombolysis registry patients with known outcomes enrolled in 2010 to 2017. END was defined as an increase in National Institutes of Health Stroke Scale score ≥4 or death within 24 hours from baseline National Institutes of Health Stroke Scale. We determined the incidence of END and used logistic regression models to inspect its associated factors. We adjusted for variables found significant in univariate analyses ( P Results: We excluded 53 539 patients and included 50 726 patients. The incidence of END was 3415/50 726 (6.7% [95% CI, 6.5%–7.0%]). Factors independently associated with END on multivariate analysis were intracerebral hemorrhage (OR, 3.23 [95% CI, 2.96–3.54], P P P P P P Conclusions: The routinely observed rate of END reflected by real-world data is low, but END greatly increases risk of disability and mortality. Readily identifiable factors predict END and may help with understanding causal mechanisms to assist prevention of END. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|