Signatures in the gut microbiota of Japanese infants who developed food allergies in early childhood
| Autor: | Kenji Sonomoto, Aki Kuroda, Chikako Kiyohara, Rie Momoda, Jiro Nakayama, Masakazu Washio, Yuka Saito, Yuki Korenori, Takako Kobayashi, Masaru Tanaka |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Allergy Weissella 030106 microbiology Gut flora Applied Microbiology and Biotechnology Microbiology 03 medical and health sciences Feces Clostridium Japan Food allergy medicine Weaning Humans Microbiome Prospective Studies Child Phylogeny Ecology biology Bacteria Infant biology.organism_classification medicine.disease Gastrointestinal Microbiome 030104 developmental biology Child Preschool Immunology Female Food Hypersensitivity |
| Zdroj: | FEMS microbiology ecology. 93(8) |
| ISSN: | 1574-6941 |
| Popis: | Bacterial colonization in infancy is considered crucial for the development of the immune system. Recently, there has been a drastic increase in childhood allergies in Japan. Therefore, we conducted a prospective study with 56 infants on the relationship between gut microbiota in the first year of life and the development of allergies during the first 3 years. In the lactation period, organic acid producers such as Leuconostoc, Weissella and Veillonella tended to be underrepresented in subjects who developed food allergies (FA, n = 14) within the first two years. In the weaning period, children in the FA group were highly colonized by unclassified Enterobacteriaceae and two Clostridium species closely related to Clostridium paraputrificum and C. tertium, and the whole tree phylogenetic diversity index was significantly lower in the FA group. All of these differences in the weaning period were statistically significant, even after adjusting for potential confounding factors. A higher abundance of unclassified Enterobacteriaceae was also found in the other allergic group (n = 15), whereas the two Clostridium species were highly specific to the FA group. The mode of action of these Clostridium species in childhood food allergies remains unknown, warranting further investigation. |
| Databáze: | OpenAIRE |
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