The effect of hydrogen sulfide on electrical and contractile activity of smooth muscle cells in guinea pig ureter

Autor:	M. A. Medvedev, M. B. Baskakov, S. N. Orlov, D. S. Nosov, A. S. Zheludeva, I. V. Kovalyov, L. V. Smagliy, T. A. Vtorushina, O. S. Rozhkova, S. V. Gusakova
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	chemistry.chemical_compound chemistry Smooth muscle Hydrogen sulfide Biophysics hydrogen sulfide Molecular Medicine biologically active substances Medicine Guinea pig ureter potassium conductance of the membrane smooth muscle cells
Zdroj:	Bûlleten' Sibirskoj Mediciny, Vol 11, Iss 6, Pp 51-58 (2012)
ISSN:	1819-3684 1682-0363
Popis:	The effect of donor hydrogen sulfide NaHS for electrical and contractile activity of smooth muscle cells in guinea pig ureter is present in biologically active compounds histamine and phenylephrine, an activator of adenylate cyclase forskolin, blockers of Na+/H+-exchanger, Na+,K+,2Cl–-cotransporter and potassium conductance of the membrane were studied by the method of the double sucrose gap junction. It is shown that the activating effect of NaHS largely determined by the interference of Na+-mediated ion transporters in the cAMP-dependent inhibition of the potassium conductance of the membrane of smooth muscle cells.
Databáze:	OpenAIRE
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