Towards 3D in vitro models for the study of cardiovascular tissues and disease
| Autor: | Alan J. Ryan, Fergal J. O'Brien, Steven W. Kerrigan, Claire Brougham, Carolina D. Garciarena |
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| Přispěvatelé: | This work was supported by the Irish Heart Foundation (grant number 1045940) to FJO’B and CMB, the European Research Council European Community’s Seventh Framework Programme (FP7/2007-2013) to FJO’B and the Science Foundation Ireland Career Development Award (grant number 13/CDA/2119) to SWK. |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Medical Biotechnology 3d model Disease Biology Bioinformatics Models Biological 03 medical and health sciences Tissue engineering In vivo Drug Discovery medicine Animals Humans Circulatory and Respiratory Physiology Pharmacology Myocardial tissue Tissue Engineering cardiovascular Myocardium 3D Models Heart Valves In vitro 030104 developmental biology Drug development Cardiovascular Diseases Blood Vessels |
| Zdroj: | Articles |
| ISSN: | 1878-5832 |
| Popis: | The field of tissue engineering is developing biomimetic biomaterial scaffolds that are showing increasing therapeutic potential for the repair of cardiovascular tissues. However, a major opportunity exists to use them as 3D in vitro models for the study of cardiovascular tissues and disease in addition to drug development and testing. These in vitro models can span the gap between 2D culture and in vivo testing, thus reducing the cost, time, and ethical burden of current approaches. Here, we outline the progress to date and the requirements for the development of ideal in vitro 3D models for blood vessels, heart valves, and myocardial tissue. |
| Databáze: | OpenAIRE |
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