Possible unrecognised liver injury is associated with mortality in critically ill COVID-19 patients
| Autor: | Rita García, Mario Romero-Cristóbal, Jamil Cedeño, Aranzazu Caballero, Patricia Piñeiro, Ana Clemente-Sánchez, Clara Ramos, Diego Rincón, Pablo García-Olivares, Javier Hortal, Diego-Andrés Hernández, Jose-Eugenio Guerrero, Julia Del Río, Miguel Cova, Rafael Bañares, Ignacio Garutti, Laura Rayón |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Liver injury
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) liver diseases Critically ill business.industry coronavirus Gastroenterology biomarkers Disease Acute respiratory distress RC799-869 Diseases of the digestive system. Gastroenterology medicine.disease_cause medicine.disease Chronic liver disease survival analysis critical care Internal medicine medicine business Survival analysis Original Research Coronavirus |
| Zdroj: | Therapeutic Advances in Gastroenterology, Vol 14 (2021) Therapeutic Advances in Gastroenterology |
| ISSN: | 1756-2848 |
| Popis: | Background: Coronavirus disease (COVID-19) with acute respiratory distress syndrome is a life-threatening condition. A previous diagnosis of chronic liver disease is associated with poorer outcomes. Nevertheless, the impact of silent liver injury has not been investigated. We aimed to explore the association of pre-admission liver fibrosis indices with the prognosis of critically ill COVID-19 patients. Methods: The work presented was an observational study in 214 patients with COVID-19 consecutively admitted to the intensive care unit (ICU). Pre-admission liver fibrosis indices were calculated. In-hospital mortality and predictive factors were explored with Kaplan–Meier and Cox regression analysis. Results: The mean age was 59.58 (13.79) years; 16 patients (7.48%) had previously recognised chronic liver disease. Up to 78.84% of patients according to Forns, and 45.76% according to FIB-4, had more than minimal fibrosis. Fibrosis indices were higher in non-survivors [Forns: 6.04 (1.42) versus 4.99 (1.58), p Conclusion: Unrecognised liver fibrosis, assessed by serological tests prior to admission, is independently associated with a higher risk of death in patients with severe COVID-19 admitted to the ICU. |
| Databáze: | OpenAIRE |
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