Octreotide bolus injection and azygos blood flow in patients with cirrhosis: is the effect really predictable?
| Autor: | Laurent Spahr, Antoine Hadengue, Gilles Mentha, Emiliano Giostra |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Liver Cirrhosis Male Mean arterial pressure Hypertension Portal/ drug therapy/physiopathology Cirrhosis Time Factors Haemodynamic response Portal venous pressure Thermodilution Octreotide Gastrointestinal Agents/administration & dosage/pharmacology Azygos Vein/drug effects Bolus (medicine) Gastrointestinal Agents Liver Cirrhosis Alcoholic Hypertension Portal Medicine Humans Portal Pressure/ drug effects Octreotide/administration & dosage/ pharmacology Aged ddc:616 ddc:617 business.industry Gastroenterology Hemodynamics Liver Cirrhosis/ complications/drug therapy Blood flow Middle Aged medicine.disease Portal Pressure Liver Cirrhosis Alcoholic/complications Anesthesia Azygos Vein Portal hypertension Female sense organs business medicine.drug |
| Zdroj: | Journal of Clinical Gastroenterology, Vol. 44, No 9 (2010) pp. e206-209 |
| ISSN: | 1539-2031 0192-0790 |
| Popis: | BACKGROUND: Octreotide (OCT) improves the management of variceal bleeding, but the pattern of administration is not clearly defined. Available data show a transient decrease in portal pressure and azygos blood flow (AzBF) after OCT bolus injection with desensitization at readministration. AIM: To explore the sustained hemodynamic effects of OCT and changes associated with readministration at 60 minutes on AzBF in patients with portal hypertension. PATIENTS AND METHODS: AzBF was measured invasively (thermodilution technique) in 12 patients at baseline and at 10 minutes intervals after OCT 50-mug IV bolus for a total of 60 minutes. Readministration of OCT was followed by AzBF measurement for another 15 minutes. Patients [age 51.4 y (30 to 69)] had cirrhosis (alcoholic in 9 patients; Pugh's score 8.8+/-0.3), portal hypertension (HVPG 19+/-1 mm Hg), and elevated AzBF (658+/-138 mL/min). RESULTS: The bolus of OCT was followed at 10 minutes by a 34% decline in AzBF as compared with baseline value. This AzBF reduction was sustained over the 60-minute study period (-36%+/-1.4%) with the values that remained decreased as compared with baseline (P |
| Databáze: | OpenAIRE |
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