Characteristics of Children Whose Siblings Have Fetal Alcohol Syndrome or Incomplete Fetal Alcohol Syndrome
| Autor: | Joseph F. Borzelleca, Gary R. Leonardson, Martha Neff-Smith, Valborg L. Kvigne, Thomas K. Welty |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Developmental Disabilities Fetal alcohol syndrome Child Behavior Disorders Foster Home Care Craniofacial Abnormalities Pregnancy Risk Factors medicine Humans Sibling Child Retrospective Studies business.industry Siblings medicine.disease United States Maternal alcohol Hospitalization Cross-Sectional Studies Fetal Alcohol Spectrum Disorders Case-Control Studies Pediatrics Perinatology and Child Health Indians North American Female business |
| Zdroj: | Pediatrics. 123:e526-e533 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.2008-2423 |
| Popis: | OBJECTIVE. To describe the clinical features of American Indian children born just before and just after a sibling with fetal alcohol syndrome or incomplete fetal alcohol syndrome.METHODS. Two retrospective case-control studies were conducted of Northern Plains American Indian children with fetal alcohol syndrome or incomplete fetal alcohol syndrome identified from 1981 to 1993 by using International Classification of Diseases, Ninth Revision, Clinical Modification code 760.71.RESULTS. Compared with the controls, the 39 siblings born just before children with fetal alcohol syndrome (study 1) and 30 siblings born just before children with incomplete fetal alcohol syndrome (study 2) had more facial dysmorphology (23.1% and 16.7%, respectively), growth delay (38.5% and 10.0%), and central nervous system impairment (48.7% and 33.3%). The 20 siblings born just after children with fetal alcohol syndrome (study 1) and 22 siblings born just after children with incomplete fetal alcohol syndrome (study 2) had more facial dysmorphology (20.0% and 9.1%, respectively), growth delay (45.0% and 22.7%), and central nervous system impairment (50.0% and 31.8%) than the control siblings.CONCLUSIONS. The “before” siblings had characteristics of fetal alcohol syndrome that could have predicted that the next child was at risk for fetal alcohol syndrome. The “after” siblings had better outcomes than the previous siblings with fetal alcohol syndrome, a finding that was associated with a decrease in maternal alcohol consumption during the after-sibling pregnancy. |
| Databáze: | OpenAIRE |
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