Association of plasma adipokines with chronic obstructive pulmonary disease severity and progression
| Autor: | Jin Woo Kim, Hye Yun Park, Myung Jae Park, Changhoon Lee, Hye Sook Choi, Eun Kyung Kim, Sook Young Woo, Sang Yeub Lee, Yong Il Hwang, Joon Beom Seo, Jae Seung Lee, Ji Yong Moon, Su-Young Kim, Hye Kyeong Park, Young Sam Kim, Joo Ock Na, Chin Kook Rhee, Byeong-Ho Jeong, Seong Yong Lim, Changhwan Kim, Joo Hun Park, Kwang Ha Lee, Hyoung Kyu Yoon, Jin Won Huh, Seung Soo Sheen, Kwang Ha Yoo, Sang Min Lee, Doh Hyung Kim, Seung Won Ra, Yeon-Mok Oh, Don D. Sin, Ji Hyun Lee, Ji Ye Jung, Sang Do Lee, Ho Il Yoon, Woo Jin Kim, Tae Hyung Kim, Tae Rim Shin, Yoon Ki Hong, In A. Jeong, Hojoong Kim, Kang Hyeon Choi, Jin Hwa Lee, S.S. Lee, Sei Won Lee, Yong Bum Park |
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| Rok vydání: | 2015 |
| Předmět: |
Pulmonary and Respiratory Medicine
Leptin Male medicine.medical_specialty Adipokine Pulmonary disease Computed tomography Severity of Illness Index Cohort Studies Pulmonary Disease Chronic Obstructive Internal medicine Republic of Korea medicine Humans Aged Emphysema COPD Adiponectin medicine.diagnostic_test business.industry digestive oral and skin physiology Editorials nutritional and metabolic diseases Middle Aged medicine.disease Obstructive lung disease respiratory tract diseases Respiratory Function Tests Endocrinology Cohort Disease Progression Linear Models Female business hormones hormone substitutes and hormone antagonists Biomarkers |
| Zdroj: | Annals of the American Thoracic Society. 12(7) |
| ISSN: | 2325-6621 |
| Popis: | Two adipokines, leptin and adiponectin, regulate metabolic and inflammatory systems reciprocally. The role of adiponectin in chronic obstructive pulmonary disease (COPD) has been studied. However, there are few data evaluating the relationship of plasma leptin with COPD severity or progression.The objective of this study was to evaluate the relationship of leptin, adiponectin, and the leptin/adiponectin ratio with COPD severity and progression according to COPD phenotypes.Plasma leptin and adiponectin levels were measured in 196 subjects with COPD selected from the Korean Obstructive Lung Disease cohort. Using a linear regression model and mixed linear regression, we determined the relationship of plasma leptin and adiponectin levels and the leptin/adiponectin ratio to COPD severity and progression over 3 years.The concentration of adiponectin in plasma positively correlated with percent emphysema on initial computed tomography (CT) (adjusted P = 0.022), whereas plasma leptin concentrations and the leptin/adiponectin ratio exhibited a significant inverse correlation with initial FEV1 (adjusted P = 0.013 for leptin and adjusted P = 0.041 for leptin/adiponectin ratio). Increased plasma leptin and leptin/adiponectin ratio were significantly associated with change in percent emphysema over 3 years (adjusted P = 0.037 for leptin and adjusted P = 0.029 for leptin/adiponectin ratio), whereas none of the adipokines demonstrated an association with FEV1 decline over the 3-year period.Plasma adiponectin and leptin vary according to COPD phenotypes. Plasma leptin and the leptin/adiponectin ratio, but not adiponectin, were significantly associated with changes in CT-assessed emphysema, suggesting a potential role as a biomarker in emphysema progression in patients with COPD. |
| Databáze: | OpenAIRE |
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