Effects of tamoxifen on the levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), 17 beta-oestradiol (E2), total and free testosterone (T) and total and free dihydrotestosterone (DHT) in blood of patients with benign prostatic hyperplasia
| Autor: | Poppe I, Th. Geier, Günter Dörner, D. Schnorr, Wolfgang Rohde, F. Stahl |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism Prostatic Hyperplasia Gonadotropic cell Follicle-stimulating hormone Endocrinology Internal medicine polycyclic compounds Internal Medicine medicine Humans Testosterone Estradiol business.industry Dihydrotestosterone General Medicine Free dihydrotestosterone 17beta estradiol Hyperplasia Luteinizing Hormone medicine.disease Prolactin Hormones Tamoxifen Follicle Stimulating Hormone Luteinizing hormone business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Experimental and clinical endocrinology. 82(1) |
| ISSN: | 0232-7384 |
| Popis: | Treatment of 9 patients with benign prostatic hyperplasia with 20 mg tamoxifen daily for 6 weeks resulted in a significant increase of LH (211%), FSH (215%), E2 (231%), total T (157%), free T (148%) and total DHT (148%) levels in blood. The increase of plasma free DHT (152%) levels was not significant and PRL concentrations in serum were unchanged during treatment. Comparison of the increases between total T and free T, total T and total DHT as well as free T and free DHT failed to reveal any significant differences. These results imply (1) a marked anti-oestrogenic effect of tamoxifen at the level of hypothalamo-hypophysial axis (2) no effect at the hepatic oestrogen receptor sites indicated by unchanged SHBG-bound T and DHT in plasma and (3) no significant inhibitory effect of tamoxifen on 5 alpha-reductase activity concluded from the T/DHT ratio in peripheral circulation. In view of these findings tamoxifen appears to be unsuitable for therapy of benign prostatic hyperplasia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|