Chromosome Analysis of Postimplantation Stage Embryos for Studying Possible Causes of Developmental Abnormalities in Nonobese Diabetic Mice
| Autor: | Seiichi Ando, Osamu Tanaka, Hiroki Otani, Hiroyuku Naora, Reiko Tatewaki, Ryuju Hashimoto |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
animal structures Litter Size Ratón Pregnancy in Diabetics Embryonic Development Chromosome Disorders Nod Biology Mice Mice Inbred NOD Pregnancy Internal medicine Diabetes mellitus medicine Genetic predisposition Animals NOD mice Chromosome Aberrations Mice Inbred ICR Karyotype Embryo medicine.disease Fetal Diseases Diabetes Mellitus Type 1 Endocrinology embryonic structures Pediatrics Perinatology and Child Health Gestation Female Developmental Biology |
| Zdroj: | Neonatology. 60:395-402 |
| ISSN: | 1661-7819 1661-7800 |
| DOI: | 10.1159/000243438 |
| Popis: | The chromosomes of postimplantation stage embryos of nonobese diabetic (NOD) mice were analyzed to investigate the causal mechanism of congenital anomalies in diabetic pregnancies. Postimplantation stage embryos (day 12 of gestation) in diabetic (NOD-DM) and nondiabetic (NOD-N) NOD mice had either a high or low incidence of chromosomal abnormalities. A large majority of externally normal embryos from NOD-DM and NOD-N mice had low incidences. A high incidence of chromosomal abnormalities was found in externally abnormal embryos of NOD-DM and NOD-N mice, and in a smaller number of externally normal NOD-N and NOD-DM embryos. No control ICR embryo manifested a high incidence of chromosomal abnormalities. In the NOD-DM embryos, the chromosomes appeared to be influenced by long-term maternal diabetic conditions, while high incidences of chromosomal abnormalities in the NOD-N embryos suggested a probable cause by other factor(s) (e.g. a genetic predisposition) or by a very mild diabetic condition because the NOD-N mice were prediabetic. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|