A full life-cycle bioassay with Cantareus aspersus shows reproductive effects of a glyphosate-based herbicide suggesting potential endocrine disruption

Autor: Frédéric Gimbert, Renaud Scheifler, Annette de Vaufleury, Coline Druart
Přispěvatelé: Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), ADEME (Agence De l’Environnement et de la Maîtrise de l’Energie) and the Regional Council of Franche-Comté., Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
" Fertility"
Health
Toxicology and Mutagenesis
Snails
0211 other engineering and technologies
[ SDV.TOX.ECO ] Life Sciences [q-bio]/Toxicology/Ecotoxicology
02 engineering and technology
Snail
010501 environmental sciences
Endocrine Disruptors
Toxicology
" Diquat"
01 natural sciences
chemistry.chemical_compound
Bioassay
Mating
"Endocrine disruption"
media_common
Reproduction
General Medicine
Fecundity
Pollution
medicine.anatomical_structure
Biological Assay
[SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology
Gonad
media_common.quotation_subject
Glycine
Zoology
Embryonic Development
Endocrine System
Biology
Diquat
Risk Assessment
biology.animal
"Pesticide"
medicine
Animals
" Sublethal effects"
Gonads
0105 earth and related environmental sciences
021110 strategic
defence & security studies
Life Cycle Stages
Herbicides
" Nonylphenol"
Pesticide
Fertility
chemistry
Zdroj: Environmental Pollution
Environmental Pollution, Elsevier, 2017, 226, pp.240-249. 〈10.1016/j.envpol.2017.03.061〉
Environmental Pollution, Elsevier, 2017, 226, pp.240-249. ⟨10.1016/j.envpol.2017.03.061⟩
ISSN: 0269-7491
1873-6424
DOI: 10.1016/j.envpol.2017.03.061〉
Popis: International audience; A full life-cycle (240 days) bioassay using the terrestrial snail, Cantareus aspersus, allowing exposureduring embryogenesis and/or the growth and reproduction phases, was used to assess the effects ofBypass®, a glyphosate-based herbicide (GlyBH), on a range of endpoints, including parameters underendocrine control. As a positive control, a mixture (R-A) made of diquat (Reglone®) and nonylphenols (NP, Agral®), known for its endocrine disrupting effects in other organisms, was tested. At environmental concentrations, both pesticides (R-A mixture and GlyBH) enhanced growth but reduced reproduction. The R-A mixture acted mainly on the fecundity through a delay in egg-laying of approximately 20 days and a strongly reduced number of clutches. This latter dysfunction may be caused by a permanent eversion of the penis, suggesting a disrupting effect at the neuro-endocrine level, which prevented normal mating. GlyBH acted on fertility, possibly due to a decrease in the fertilization of eggs laid by adults exposed during their embryonic development. These results, associated with the absence of observed effects on gonad histology of GlyBH exposed snails, suggested that the underlying mechanisms are neuro-endocrine.
Databáze: OpenAIRE
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