Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes

Autor: Melissa Amrein, Stephanie Meier, Ibrahim Schäfer, Sabine Schaedelin, Eline Willemse, Pascal Benkert, Joan Walter, Christian Puelacher, Tobias Zimmermann, Daniela Median, Caroline Egli, David Leppert, Raphael Twerenbold, Michael Zellweger, Jens Kuhle, Christian Mueller
Přispěvatelé: Neurochemistry Laboratory
Rok vydání: 2023
Předmět:
Zdroj: Biomarkers, 28(3), 341-351. Informa Healthcare
Amrein, M, Meier, S, Schäfer, I, Schaedelin, S, Willemse, E, Benkert, P, Walter, J, Puelacher, C, Zimmermann, T, Median, D, Egli, C, Leppert, D, Twerenbold, R, Zellweger, M, Kuhle, J & Mueller, C 2023, ' Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes ', Biomarkers, vol. 28, no. 3, pp. 341-351 . https://doi.org/10.1080/1354750X.2023.2172211
ISSN: 0183-8148
1354-750X
DOI: 10.6084/m9.figshare.22084346
Popis: Background: Functionally relevant coronary artery disease (fCAD), causing symptoms of myocardial ischemia, can currently only be reliably detected with advanced cardiac imaging. Serum neurofilament light chain (sNfL) is a biomarker for neuro-axonal injury known to be elevated by cardiovascular (CV) risk factors and cerebrovascular small-vessel diseases. Due to their pathophysiological similarities with fCAD and the link to CV risk factors, we hypothesised that sNfL may have diagnostic and prognostic value for fCAD and adverse cardiovascular outcomes. Methods: Of the large prospective Basel VIII study (NCT01838148), 4’016 consecutive patients undergoing cardiac work-up for suspected fCAD were included (median age 68 years, 32.5% women, 46.9% with history of CAD). The presence of fCAD was adjudicated using myocardial perfusion imaging single-photon emission tomography (MPI-SPECT) and coronary angiography. sNfL was measured using a high-sensitive single-molecule array assay. All-cause and cardiovascular death, myocardial infarction (MI), and stroke/transient ischaemic attack (TIA) during 5-year follow-up were the prognostic endpoints. Results: The diagnostic accuracy of sNfL for fCAD as quantified by the area under the curve (AUC) was low (0.58, 95%CI 0.56–0.60). sNfL was strongly associated with age, renal dysfunction, and body mass index and was a strong and independent predictor of all-cause death, cardiovascular death, and stroke/TIA but not MI. Time-dependent AUC for cardiovascular-death at 1-year was 0.85, 95%CI 0.80–0.89, and 0.81, 95%CI 0.77–0.86 at 2-years. Conclusion: While sNfL concentrations did not show a diagnostic role for fCAD, in contrast, sNfL was a strong and independent predictor of cardiovascular outcomes, including all-cause death, cardiovascular death and stroke/TIA.
Databáze: OpenAIRE
Externí odkaz: