From hallucinations to synaesthesia: A circular inference account of unimodal and multimodal erroneous percepts in clinical and drug-induced psychosis

Autor: Bouttier, Sophie Denève, Renaud Jardri, Pantelis Leptourgos
Přispěvatelé: Laboratoire de Neurosciences Cognitives & Computationnelles (LNC2), Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Yale University [New Haven], Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Lille, ANR-17-EURE-0017,FrontCog,Frontières en cognition(2017), ANR-16-CE37-0015,INTRUDE,Pensées intrusives: du décodage de l'activité fonctionnelle per-hallucinatoire en temps réel à l'innovation thérapeutique(2016), Deneve, Sophie
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Neuroscience and Biobehavioral Reviews
Neuroscience and Biobehavioral Reviews, 2022, 135 (1), pp.104593. ⟨10.1016/j.neubiorev.2022.104593⟩
ISSN: 0149-7634
1873-7528
Popis: International audience; Psychedelics distort perception and induce visual and multimodal hallucinations as well as synaesthesia. This is in contradiction with the high prevalence of distressing voices in schizophrenia. Here we introduce a unifying account of unimodal and multimodal erroneous percepts based on circular inference. We show that amplification of top-down predictions (descending loops) leads to an excessive reliance on priors and aberrant levels of integration of the sensory representations, resulting in crossmodal percepts and stronger illusions. By contrast, amplification of bottom-up information (ascending loops) results in overinterpretation of unreliable sensory inputs and high levels of segregation between sensory modalities, bringing about unimodal hallucinations and reduced vulnerability to illusions. We delineate a canonical microcircuit in which layer-specific inhibition controls the propagation of information across hierarchical levels: inhibitory interneurons in the deep layers exert control over priors, removing descending loops. Conversely, inhibition in the supragranular layers counterbalances the effects of the ascending loops. Overall, we put forward a multiscale and transnosographic account of erroneous percepts with important theoretical, conceptual and clinical implications.
Databáze: OpenAIRE
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