Docosahexaenoic Acid-Phosphatidylcholine Improves Cognitive Deficits in an A?23-35-Induced Alzheimer's Disease Rat Model
| Autor: | Guo Du Wang, Zhiqin Gao, Changhu Xue, Hailin Han, Jia Wang, Xiaoyun Yang, Qingjuan Tang, Yuming Wang, Mei-Hua Qu |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Gerontology medicine.medical_specialty Docosahexaenoic Acids Morris water navigation task Hippocampus Pathogenesis chemistry.chemical_compound Alzheimer Disease Phosphatidylcholine Internal medicine Drug Discovery medicine Animals Rats Wistar Vascular dementia Amyloid beta-Peptides business.industry Decapodiformes General Medicine medicine.disease Peptide Fragments Rats Cortex (botany) Disease Models Animal Endocrinology chemistry Docosahexaenoic acid Phosphatidylcholines Female Alzheimer's disease Cognition Disorders business |
| Zdroj: | Current Topics in Medicinal Chemistry. 16:558-564 |
| ISSN: | 1568-0266 |
| Popis: | Both Docosahexaenoic acid (DHA) and Phosphatidylcholine (PC) have been shown to halt the pathogenesis of Alzheimer disease (AD) and vascular dementia. This study aimed to investigate the role of DHA-containing PC (DHA-PC) in the improvement of Aβ 25-35 -induced cognitive deficits in rats. Aβ 25-35 -induced AD rats were treated for 30 days with DHA-PC, which was extracted from Sthenoteuthis oualaniensis spawns . Cognitive improvement of the AD rats was detected using the Morris water maze (MWM). The results demonstrated that DHA-PC could improve the learning and memory abilities of AD rats in a dose-dependent pattern. Further analyses showed that expression of phosphorylated tau decreased, and the neuronal morphology recovered in brains of DHA-PC-treated AD rats, as compared with mock-treated AD rats. In addition, DHAPC treatment increased the activity of GSH-Px and SOD in the cortex and hippocampus of AD rats. Taken together, these data suggest that DHA-PC is able to improve the cognitive deficits in AD rats, probably through decreasing the phosphorylation of tau in the cortex and hippocampus CA1 area, and increasing the GSH-Px and SOD activities in the brain of AD rats. |
| Databáze: | OpenAIRE |
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