Comparative kinetics of serum and vitreous humor digoxin concentrations in a guinea pig model. Part I: Intravenous administration of digoxin
| Autor: | J. H. Bidanset, Brian Donnelly, Joseph Balkon, Michael A. Barletta, Albert A. Belmonte, Thomas Manning |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Digoxin Health Toxicology and Mutagenesis Kinetics Guinea Pigs Digitalis Pharmacology Toxicology Analytical Chemistry Guinea pig Iodine Radioisotopes Pharmacokinetics polycyclic compounds medicine Environmental Chemistry Distribution (pharmacology) Animals cardiovascular diseases Chemical Health and Safety biology Chemistry biology.organism_classification eye diseases carbohydrates (lipids) Vitreous Body Cardiovascular agent Injections Intravenous Indicators and Reagents sense organs Biological half-life medicine.drug |
| Zdroj: | Journal of analytical toxicology. 15(2) |
| ISSN: | 0146-4760 |
| Popis: | The pharmacokinetics of a single intravenous dose of digoxin in the guinea pig was investigated with emphasis on the penetration of digoxin into the vitreous humor. A controlled study was undertaken and data was collected which indicated that digoxin follows an open, two-compartment pharmacokinetic model with a terminal half-life of 318 minutes. The data indicated that the ratio of vitreous concentrations to serum concentrations were determined to be equal following an initial tissue distribution phase. |
| Databáze: | OpenAIRE |
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