Alignments of endocrine, anthropometric, and metabolic parameters in type 2 diabetes after intervention with an Okinawa-based Nordic diet
| Autor: | Gassan Darwiche, Bodil Roth, Peter Höglund, Bodil Ohlsson |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
gut hormones medicine.medical_treatment Okinawa-based Nordic diet Adipokine lcsh:TX341-641 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Glucagon 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Medicine adipokines Nutrition and Dietetics business.industry Leptin Insulin digestive oral and skin physiology Public Health Environmental and Occupational Health metabolic control medicine.disease Endocrinology Original Article Ghrelin Resistin business lcsh:Nutrition. Foods and food supply hormones hormone substitutes and hormone antagonists incretins Food Science |
| Zdroj: | Food & Nutrition Research Food & Nutrition Research, Vol 62, Iss 0, Pp 1-12 (2018) |
| ISSN: | 1654-661X |
| DOI: | 10.29219/fnr.v62.1328 |
| Popis: | Background: An Okinawa-based Nordic diet with moderately low carbohydrate content and high fat and protein content has been shown to improve anthropometry and metabolism in type 2 diabetes. Objective: The objectives of this study were to measure plasma or serum levels of hormones regulating energy metabolism and metabolic control, that is, cholecystokinin (CCK), Cortisol, C-peptide, ghrelin, glucagon, glucagon- like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, leptin, plasminogen activator inhibitor-1 (PAI-1), polypeptide YY (PYY), resistin, and visfatin after this diet intervention, and to determine partial correlations between hormonal levels and anthropometric and metabolic responses. Design: A total of 30 patients (17 women) with type 2 diabetes, mean age 57.5 ± 8.2 years, and body mass index (BMI) 29.9 ± 4.1 kg/m2 were served the diet for 12 weeks. Fasting hormones were measured by Luminex and enzyme–linked immunosorbent assay (ELISA) before study start and after 12 and 28 weeks, along with anthropometric and metabolic parameters. Result: The levels of CCK (P = 0.005), cortisol (P = 0.015), C-peptide (P = 0.022), glucagon (P = 0.003), GLP-1 (P = 0.013), GIP (P < 0.001), insulin (P = 0.004), leptin (P < 0.001), and PYY (P < 0.001) were lowered after dietary intervention. These reduced levels only remained for PYY at week 28 (P = 0.002), when also ghrelin (P = 0.012) and visfatin (P = 0.021) levels were reduced. Changes of glucose values correlated with changed levels of C-peptide and PYY (P < 0.001), insulin (P = 0.002), and PAI-1 (P = 0.009); changes of triglyceride values with changed levels of C-peptide, insulin, and PYY (P < 0.001) and PAI-1 (P = 0.005); changes of insulin resistance with changes of leptin levels (P = 0.003); and changes of BMI values with changed levels of C-peptide, insulin, and leptin (P < 0.001). Conclusions: Okinawa-based Nordic diet in type 2 diabetes has significant impact on the endocrine profile, which correlates with anthropometric and metabolic improvements. |
| Databáze: | OpenAIRE |
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