Translational Safety Biomarkers of Kidney Injury
| Autor: | Shashi Amur, Rupesh P. Amin, Katerina Vlasakova, Sean P. Troth, Warren E. Glaab |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry 030232 urology & nephrology Acute kidney injury Acute Kidney Injury Kidney Function Tests medicine.disease Pre-clinical development Translational Research Biomedical Clinical trial MicroRNAs 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Nephrology medicine Kidney injury Humans Biomarker (medicine) Intensive care medicine business Early phase Clinical evaluation Biomarkers |
| Zdroj: | Seminars in Nephrology. 39:202-214 |
| ISSN: | 0270-9295 |
| Popis: | Acute kidney injury continues to be a common problem and there continues to be a medical need for sensitive translational biomarkers for clinical monitoring. The past decade has yielded unprecedented progress in fundamental research into novel kidney biomarker evaluation and the mechanistic understanding of kidney injury; as such, these novel biomarkers increasingly are being used in preclinical drug development and in early clinical trials of drug candidates on a case-by-case basis, as well as in medical and veterinary practice. With the recent successful clinical qualification of a subset of novel accessible biomarker candidates for use in early phase clinical trials, continued clinical evaluation may enable expanded regulatory qualification for more generalized clinical use. This review provides a comprehensive overview about the discovery and development of kidney safety biomarkers with a focus on current progress in nonclinical research, progress toward translation to the clinic, and perspectives on future opportunities. |
| Databáze: | OpenAIRE |
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