Antioxidant, Lipid Lowering, and Membrane Stabilization Effect of Sesamol against Doxorubicin-Induced Cardiomyopathy in Experimental Rats
Autor: | Anusha Chennuru, Mohamed T. S. Saleem |
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Jazyk: | angličtina |
Rok vydání: | 2013 |
Předmět: |
Male
Very low-density lipoprotein Cardiotonic Agents Article Subject Cardiomyopathy lcsh:Medicine Pharmacology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Antioxidants Lipid peroxidation chemistry.chemical_compound Phenols medicine Animals Doxorubicin Benzodioxoles Rats Wistar Sesamol Cardioprotection Antibiotics Antineoplastic General Immunology and Microbiology Cholesterol Myocardium lcsh:R Cell Membrane General Medicine medicine.disease Lipids Rats Oxidative Stress chemistry lipids (amino acids peptides and proteins) Female Lipid Peroxidation Cardiomyopathies Oxidative stress medicine.drug Research Article |
Zdroj: | BioMed Research International BioMed Research International, Vol 2013 (2013) |
ISSN: | 2314-6141 2314-6133 |
Popis: | The present study was designed to evaluate the cardioprotective effect of sesamol against doxorubicin-induced cardiomyopathy in rats. In this study, the cardioprotective effect of sesamol against doxorubicin induced cardiomyopathy in experimental rats was evaluated at the dosage of 50 mg/kg bw. Doxorubicin was administered to rats at a total cumulative dose of 15 mg/kg through intraperitoneal route for 2 weeks in six-divided dose on 8th, 10th, 14th, 16th, 18th, and 21st day. After the last dose administration, the endogenous antioxidants and lipid peroxidation were estimated in heart tissue homogenate. Cardiac biomarkers such as troponin T, LDH, CK, and AST and lipid profiles such as cholesterol, triglycerides, HDL, LDL, and VLDL were estimated in serum. Sesamol has cardioprotective activity through normalization of doxorubicin-induced-altered biochemical parameters. Biochemical study was further supported by histopathological study, which shows that sesamol offered myocardial protection from necrotic damage. From these findings, it has been concluded that the sesamol has significant cardioprotection against doxorubicin induced cardiomyopathy via amelioration of oxidative stress, lipid lowering, and membrane stabilization effect. |
Databáze: | OpenAIRE |
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