Polygenic Risk and the Course of Attention-Deficit/Hyperactivity Disorder From Childhood to Young Adulthood: Findings From a Nationally Representative Cohort
| Autor: | Guilherme V. Polanczyk, Karen Sugden, Daniel W. Belsky, Benjamin Williams, Terrie E. Moffitt, Jessica Agnew-Blais, Jasmin Wertz, Louise Arseneault, Avshalom Caspi, Andrea Danese, Cathryn M. Lewis |
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| Rok vydání: | 2021 |
| Předmět: |
Multifactorial Inheritance
Adolescent longitudinal Population Poison control Impulsivity Young Adult mental disorders Developmental and Educational Psychology medicine Humans ADHD Attention deficit hyperactivity disorder 0501 psychology and cognitive sciences Longitudinal Studies Young adult Child education development education.field_of_study business.industry 05 social sciences Alcohol dependence New Research medicine.disease Twin study Psychiatry and Mental health Attention Deficit Disorder with Hyperactivity Child Preschool polygenic risk score Cohort medicine.symptom business Genome-Wide Association Study 050104 developmental & child psychology Clinical psychology |
| Zdroj: | Agnew-Blais, J C, Belsky, D W, Caspi, A, Danese, A, Moffitt, T E, Polanczyk, G V, Sugden, K, Wertz, J, Williams, B S, Lewis, C M & Arseneault, L 2021, ' Polygenic risk and the course of Attention-Deficit/Hyperactivity Disorder from childhood to young adulthood : Findings from a nationally representative cohort ', Journal of the american academy of child and adolescent psychiatry, vol. 60, no. 9, pp. 1147-1156 . https://doi.org/10.1016/j.jaac.2020.12.033 Journal of the American Academy of Child and Adolescent Psychiatry |
| ISSN: | 0890-8567 |
| DOI: | 10.1016/j.jaac.2020.12.033 |
| Popis: | OBJECTIVE: To understand whether genetic risk for attention-deficit/hyperactivity disorder (ADHD) is associated with the course of the disorder across childhood and into young adulthood.METHOD: Participants were from the Environmental Risk (E-Risk) Longitudinal Twin Study, a population-based birth cohort of 2,232 twins. ADHD was assessed at ages 5, 7, 10, and 12 with mother- and teacher-reports and at age 18 with self-report. Polygenic risk scores (PRSs) were created using a genome-wide association study of ADHD case status. Associations with PRS were examined at multiple points in childhood and longitudinally from early childhood to adolescence. We investigated ADHD PRS and course to young adulthood, as reflected by ADHD remission, persistence, and late onset.RESULTS: Participants with higher ADHD PRSs had increased risk for meeting ADHD diagnostic criteria (odds ratios ranging from 1.17 at age 10 to 1.54 at age 12) and for elevated symptoms at ages 5, 7, 10, and 12. Higher PRS was longitudinally associated with more hyperactivity/impulsivity (incidence rate ratio = 1.18) and inattention (incidence rate ratio = 1.14) from age 5 to age 12. In young adulthood, participants with persistent ADHD exhibited the highest PRS (mean PRS = 0.37), followed by participants with remission (mean PRS = 0.21); both groups had higher PRS than controls (mean PRS = -0.03), but did not significantly differ from one another. Participants with late-onset ADHD did not show elevated PRS for ADHD, depression, alcohol dependence, or marijuana use disorder.CONCLUSION: Genetic risk scores derived from case-control genome-wide association studies may have relevance not only for incidence of mental health disorders, but also for understanding the longitudinal course of mental health disorders. |
| Databáze: | OpenAIRE |
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