Five Years Outcomes and Predictors of Events in a Single-Center Cohort of Patients Treated with Bioresorbable Coronary Vascular Scaffolds

Autor:	Annika Mühlenhaus, Remzi Anadol, Thomas Münzel, Tommaso Gori, Ann-Kristin Trieb, Alberto Polimeni
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Target lesion medicine.medical_specialty medicine.medical_treatment lcsh:Medicine 030204 cardiovascular system & hematology Single Center Article coronary stent 03 medical and health sciences restenosis 0302 clinical medicine Restenosis Coronary stent medicine 030212 general & internal medicine thrombosis bioresorbable scaffolds Proportional hazards model business.industry Incidence (epidemiology) lcsh:R General Medicine medicine.disease Thrombosis Surgery Cohort business
Zdroj:	Journal of Clinical Medicine Volume 9 Issue 3 Journal of Clinical Medicine, Vol 9, Iss 3, p 847 (2020)
ISSN:	2077-0383
DOI:	10.3390/jcm9030847
Popis:	Introduction: We report outcome data of patients treated with coronary bioresorbable scaffolds up to 5 years and investigate predictors of adverse events. Methods: Consecutive patients treated with at least one coronary bioresorbable scaffold (BRS, Abbott Vascular, Santa Clara, USA) between May 2012 and May 2014 in our center were enrolled. Clinical/procedural characteristics and outcome data at 1868 (1641&ndash 2024) days were collected. The incidence of scaffold thrombosis (ScT), restenosis (ScR), and target lesion failure (TLF) and their predictors were investigated using Kaplan&ndash Meier and Cox regression analysis. Results: 512 consecutive patients and 598 lesions were included in the database. A total of 30 ScT, 42 ScR, and 92 TLF were reported. The rate of ScT was 3.6% in the first year, 2.2% in the second&ndash third year, and 0.6% in the fourth&ndash fifth year after implantation. The corresponding rates of ScR were 2.5%, 5.7%, and 1.1%. The corresponding incidence of TLF was 8.8%, 8.0%, 3.8%. Procedural parameters (vessel size, scaffold footprint) and the technique used at implantation (including predilation, parameters of sizing, and postdilation) were predictors of ScT and TLF in the first three years after implantation. In contrast, only diabetes was predictive of events between 4&ndash 5 years (HR 6.21(1.99&ndash 19.40), p = 0.002). Conclusions: After device resorption, the incidence of very late adverse events in lesions/patients implanted with a BRS decreases. Procedural and device-related parameters are not predictors of events anymore.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9632714080ad9d050e21b9b031437a23 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.