Nitrendipine and superoxide dismutase in ischemic renal injury
| Autor: | Bryan L. Fandrich, Jerry S. Matsumura, Wayne K. Jacobsen, Robert D. Martin, Daniel J. Cole, Randall M. Schell, Gary Stier |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Ischemia Renal function Critical Care and Intensive Care Medicine Kidney Superoxide dismutase Rats Sprague-Dawley Random Allocation Nitrendipine Renal injury Internal medicine medicine Animals Chemotherapy biology Vascular disease business.industry Superoxide Dismutase General Medicine Acute Kidney Injury medicine.disease Rats Endocrinology medicine.anatomical_structure Nephrology Creatinine biology.protein Drug Therapy Combination business medicine.drug |
| Zdroj: | Renal failure. 16(6) |
| ISSN: | 0886-022X |
| Popis: | The effect of the Ca entry blocker nitrendipine, the antioxidant superoxide dismutase (SOD), and a combination of nitrendipine and superoxide dismutase on postischemic renal function was studied in four groups (n = 24) of rats. The rats in group 1 (n = 6) were the ischemic control and received 10 mL of 0.9% NaCl. Group II (n = 6) received SOD 7.0 mg/kg. Group III (n = 6) received nitrendipine 1 mg/kg. Group IV (n = 6) received nitrendipine 1 mg/kg and SOD 7 mg/kg. After administration, both kidneys were rendered ischemic by cross-clamping the renal vessels for 60 min. Comparison of 24-h creatinine clearance (CCr) for 3 days after reversal of ischemia revealed: (a) nitrendipine alone was the most effective in preserving renal function (p.05); (b) SOD provided some degree of improvement, but only on day 3 (p.05); (c) a similar result was detected using a combination of nitrendipine and SOD (p.05); (d) there was no significant difference between SOD and nitrendipine nor between SOD and the combination of nitrendipine/SOD; (e) there was a significant improvement with nitrendipine when compared to the combination of nitrendipine/SOD (p.05). |
| Databáze: | OpenAIRE |
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