Obesity: An Addiction? Imaging of Neurotransmitter Systems in Obesity
| Autor: | van de Giessen, Elsmarieke, McIlwrick, Silja, Veltman, Dick, van den Brink, Wim, Booij, Jan, Dierckx, Rudy A. J. O., Otte, Andreas, de Vries, Erik F. J., van Waarde, Aren, den Boer, Johan A. |
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| Přispěvatelé: | Radiology and nuclear medicine, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Nuclear Medicine, Other departments, Amsterdam Neuroscience, Adult Psychiatry, Radiology and Nuclear Medicine, ANS - Brain Imaging, ANS - Compulsivity, Impulsivity & Attention |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Addiction media_common.quotation_subject digestive oral and skin physiology medicine.disease Obesity Eating disorders chemistry.chemical_compound chemistry Binge-eating disorder Dopamine Medicine Serotonin business Psychiatry Neurotransmitter Body mass index media_common medicine.drug |
| Zdroj: | PET and SPECT in Psychiatry ISBN: 9783030572303 PET and SPECT in Psychiatry: Second Edition, 841-860 STARTPAGE=841;ENDPAGE=860;TITLE=PET and SPECT in Psychiatry: Second Edition van de Giessen, E, McIlwrick, S, Veltman, D, van den Brink, W & Booij, J 2020, Obesity : An addiction? Imaging of neurotransmitter systems in obesity . in PET and SPECT in Psychiatry: Second Edition . PET and SPECT in Psychiatry: Second Edition, Springer International Publishing, pp. 841-860 . https://doi.org/10.1007/978-3-030-57231-0_26 PET and SPECT in Psychiatry ISBN: 9783642403835 PET and SPECT in psychiatry, 641-656 STARTPAGE=641;ENDPAGE=656;TITLE=PET and SPECT in psychiatry |
| Popis: | The brain is important in the regulation of eating behavior and satiety signaling. There is also evidence that many neurotransmitters are involved in food intake regulation and eating behavior; consequently dysregulated neurotransmitter systems may be involved in the pathophysiology of obesity. This chapter presents an overview of results of neurotransmitter imaging studies in obese humans. Presently, the dopaminergic, serotonergic, noradrenergic, opioid and cannabinoid systems have been studied with molecular imaging techniques in obese humans. The major findings are increased serotonin (5-hydroxytryptamine; 5-HT) 5-HT2A receptor availability in cortical regions, a complex relationship between dopamine D2/3 receptor (DRD2/3) availability and body mass index (BMI), probably an important role of the striatal and extra-striatal mu opioid receptor, and a possible role of the cannabinoid type 1 (CB1) receptor. There is no disturbance in serotonin transporter (SERT) availability in the thalamus and midbrain or in striatal dopamine transporter (DAT) availability. The effects of bariatric surgery on neurotransmission and findings in subgroups such as patients with binge eating disorder or insulin resistance are also discussed. |
| Databáze: | OpenAIRE |
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