Stereological and histopathological evaluation of the effect of Thymoquinone on peridural fibrosis following laminectomy in rats
| Autor: | Mehmet Emin Önger, Aytac Turkoz, Dursun Türköz, Enis Kuruoglu |
|---|---|
| Přispěvatelé: | OMÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, OMÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Türköz, Dursun, Türköz, Aytaç, Önger, Mehmet, Kuruoğlu, Enis |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Epidural Space
medicine.medical_specialty Peridural fibrosis medicine.medical_treatment Phytochemicals Urology thymoquinone Vascular volume 030204 cardiovascular system & hematology Article Sham group 03 medical and health sciences chemistry.chemical_compound Postoperative Complications 0302 clinical medicine Fibrosis Benzoquinones medicine Animals Nigella sativa Thymoquinone 0303 health sciences 030306 microbiology business.industry Drug Administration Routes Laminectomy General Medicine Capillary volume medicine.disease laminectomy Rats Treatment Outcome chemistry Medicine Spinal Diseases peridural fibrosis Drug Monitoring business Bone volume |
| Zdroj: | Turkish Journal of Medical Sciences |
| DOI: | 10.3906/sag-2006-147 |
| Popis: | Tam Metin / Full Text PMID: 32892542 WOS : 000623196400046 SCI-EXPANDED Q3 This study’s aim was to investigate the effects of thymoquinone, which is the essential bioactive component of the volatile oil of Nigella sativa on the peridural fibrosis in rats following laminectomy. Materials and methods: Twenty female Wistar Albino rats were used in our study. The rats were randomly divided into 2 groups: Sham and Surgery + Thymoquinone. Both groups underwent laminectomy at L1 under general anesthesia. The Sham group was not subjected to any drug application. The 2nd group was treated with intraperitoneal 10-mg/kg thymoquinone once per day for a period of 28 days, following the same surgical procedure. All of the group specimens were sacrificed after 4 weeks, and the laminectomy area was examined in terms of new bone volume, capillary volume, and fibrosis volume using stereological approaches. Results: Statistically significant differences were found between the Sham and Surgery + Thymoquinone groups in terms of new bone volume (P = 0.01), capillary volume (P = 0.01), and fibrosis volume (P < 0.001). It was noted that Thymoquinone caused a significant increase in new bone volume, vascular volume and, a significant decrease in fibrosis volume. Conclusion: The results of our study indicate that thymoquinone is effective in decreasing peridural fibrosis when applied to a laminectomy model. Key words: Laminectomy, peridural fibrosis, thymoquinone https://pubmed.ncbi.nlm.nih.gov/32892542/ |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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