IgE mediated autoallergy against thyroid peroxidase--a novel pathomechanism of chronic spontaneous urticaria?
| Autor: | Sabine Altrichter, Martin Metz, Hans-Jürgen Peter, Dina Pisarevskaja, Marcus Maurer, Peter Martus |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male endocrine system Urticaria Lymphocyte Immunology Immunology/Autoimmunity lcsh:Medicine Enzyme-Linked Immunosorbent Assay Dermatology medicine.disease_cause Immunoglobulin E Iodide Peroxidase Autoimmune Diseases Autoimmunity Serology Thyroid peroxidase Interquartile range Hypersensitivity medicine Humans lcsh:Science Multidisciplinary biology business.industry Thyroid lcsh:R Autoantibody Middle Aged medicine.anatomical_structure Chronic Disease embryonic structures biology.protein Female lcsh:Q Immunology/Allergy and Hypersensitivity business Research Article |
| Zdroj: | PLoS ONE, Vol 6, Iss 4, p e14794 (2011) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background Chronic spontaneous urticaria (csU), which is characterized by recurrent episodes of mast cell-driven wheal and flare-type skin reactions, is often associated with elevated total IgE levels and thyroid autoimmunity. We speculate that some csU patients express IgE autoantibodies against thyroid antigens such as thyroid peroxidase (TPO), which could bind to skin mast cells and induce their activation. Methods We developed and used a site-directed human IgE capture ELISA to quantify IgE-anti-TPO. We used this assay and investigated csU patients (n = 478) and healthy control subjects (n = 127) for IgE-anti-TPO and then assessed IgE-anti-TPO-positive and -negative csU patients for clinical and serological differences. Principal Findings CsU patients were found to express more than 2fold higher IgE-anti-TPO serum levels as compared to healthy control subjects (p |
| Databáze: | OpenAIRE |
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