Hallazgos en reintervenciones quirúrgicas por cáncer de la vesícula biliar en pacientes con y sin quimio-radiación preoperatoria
| Autor: | Xabier de Aretxabala U, Juan C Araya O, Pablo Guzmán G, Juan Carlos Roa S, Luis Burgos S, ván Roa E, Miguel Villaseca H |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2001 |
| Předmět: |
Chemotherapy
medicine.medical_specialty Pathology Necrosis business.industry medicine.medical_treatment General Medicine medicine.disease Gastroenterology Gallbladder neoplasms Radiation therapy medicine.anatomical_structure Radiotherapy adjuvant Surgical procedures Celiac artery Internal medicine medicine.artery medicine Lymph medicine.symptom Gallbladder Neoplasm Gallbladder cancer business Lymph node Chemotherapy adjuvant |
| Zdroj: | Revista médica de Chile, Volume: 129, Issue: 9, Pages: 1013-1020, Published: SEP 2001 Revista médica de Chile v.129 n.9 2001 SciELO Chile CONICYT Chile instacron:CONICYT |
| Popis: | Background: The usefulness of surgery in the treatment of gallbladder cancer has not been clearly established. The benefits of chemo and radiotherapy are similarly dubious. Aim: To report the pathological findings in patients subjected to surgical reinterventions for gallbladder cancer. Patients and methods: We report 54 patients with gallbladder cancer that were subjected to a second surgical intervention for resection of liver segments IVb and V and lymph nodes corresponding to the liver hilar, portal, peripancreatic, celiac artery and periaortic territories. Thirteen of these patients were subjected to preoperative chemo-radiotherapy (4500 Gy and 5-fluouracil 500 mg/m²). Results: Lymph node metastases were found in 25 and 38%, and liver metastases in 25 and 28% of patients with or without chemo-radiotherapy respectively. The most frequent pathological findings attributed to radiation in the liver were fatty infiltration in 75% of cases, vascular transformation in 83% of cases and minimal periportal lymphocyte infiltration in 40% of cases. Lymph nodes were atrophic in 67% of cases and had foci of cortical necrosis in 46% of cases. Three cases had regional lymph node and liver metastases. Most tumor cells were viable. Conclusions: No differences in the number of lymph node or liver metastases were observed between patients with and without chemo-radiotherapy. No effect of the treatment on residual tumor was observed either (Rev Méd Chile 2001; 129: 1013-20 |
| Databáze: | OpenAIRE |
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