Characteristics and outcome of varicella-zoster virus central nervous system infections in adults
| Autor: | Y. Le Tulzo, M Tas, Florian Reizine, A. Le Bot, Charlotte Pronier, François Bénézit, Pierre Tattevin, P. Fillâtre, Matthieu Revest, Alice Ballerie, Patrick Jego |
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| Přispěvatelé: | CHU Pontchaillou [Rennes], Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CH Yves LE FOLL, Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) Herpesvirus 3 Human Pediatrics medicine.medical_specialty [SDV]Life Sciences [q-bio] 030106 microbiology Acyclovir medicine.disease_cause Antiviral Agents Herpes Zoster Virus Immunocompromised Host 03 medical and health sciences Central Nervous System Infections 0302 clinical medicine Interquartile range medicine Humans Meningitis 030212 general & internal medicine Aciclovir Aged Retrospective Studies business.industry Varicella zoster virus Meningoencephalitis Retrospective cohort study General Medicine Middle Aged Prognosis medicine.disease 3. Good health Infectious Diseases Encephalitis Varicella-zoster virus Female business medicine.drug |
| Zdroj: | European Journal of Clinical Microbiology and Infectious Diseases European Journal of Clinical Microbiology and Infectious Diseases, Springer Verlag, 2021, ⟨10.1007/s10096-021-04245-y⟩ European Journal of Clinical Microbiology and Infectious Diseases, 2021, 40 (11), pp.2437-2442. ⟨10.1007/s10096-021-04245-y⟩ |
| ISSN: | 1435-4373 0934-9723 |
| DOI: | 10.1007/s10096-021-04245-y |
| Popis: | International audience; We conducted an observational retrospective study of all adults hospitalized for documented varicella-zoster virus (VZV) meningitis or encephalitis during years 2000-2015 in one referral centre. Thirty-six patients (21 males, 15 females) were included, with meningitis (n = 21), or meningoencephalitis (n = 15). Median age was 51 years [interquartile range, 35-76], and 6 patients (17%) were immunocompromised. Aciclovir was started in 32 patients (89%), with a median dose of 11 mg/kg/8 h [10-15]. No patient died, but 12 (33%) had neurological sequelae at discharge. Age was the only variable associated with adverse outcome (OR 1.98 [1.17-3.35] per 10-year increment, P = 0.011). |
| Databáze: | OpenAIRE |
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