Cranial sonographic markers of fetal open spina bifida at 11 to 13 weeks of gestation
Autor: | Sujatha Ganesan, Matthias Scheier, D Wertaschnigg, Jayshree Ramkrishna, Tullio Ghi, Nicola Volpe, Simon Meagher, Cheryl Tse, Daniel L. Rolnik |
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Rok vydání: | 2019 |
Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Percentile Gestational Age Reference range Ultrasonography Prenatal Pregnancy Reference Values medicine Humans Fetal head Genetics (clinical) Retrospective Studies Fetus business.industry Spina bifida Skull Occipital bone Brain Obstetrics and Gynecology Gestational age medicine.disease Sagittal plane nervous system diseases Spina Bifida Cystica medicine.anatomical_structure Case-Control Studies Occipital Bone Female business Nuclear medicine Brain Stem |
Zdroj: | Prenatal Diagnosis. 40:365-372 |
ISSN: | 1097-0223 0197-3851 |
Popis: | Objectives To compare the sonographic signs of spina bifida obtained on axial and sagittal views of the fetal head between 11 and 13+6 weeks of gestation. Methods This was a retrospective study including 27 cases of spina bifida and 1003 randomly selected controls. Indirect markers of spina bifida were evaluated on stored ultrasound images. Intracranial translucency (IT), ratio between the brainstem and the brainstem-occipital bone distance (BS/BSOB), and maxillo-occipital (MO) line were assessed on sagittal view, whereas biparietal diameter (BPD), BPD to abdominal circumference ratio (BPD/AC), and aqueduct to occipital bone (aqueduct of Sylvius [AoS]) distance were measured on the axial plane. Reference ranges were developed, and cases of spina bifida were examined in relation to the reference range. Results On the sagittal view, detection rates for IT below the fifth percentile, BS/BSOB above the 95th percentile, and an abnormal MO line were 52.3%, 96.3%, and 96.3%, respectively. On the axial view, detection rates for BPD, BPD/AC, and AoS below the fifth percentile were 66.7%, 70.4%, and 77.8%, respectively. Conclusion The MO line and the BS/BSOB ratio appear to be the best indirect ultrasound markers of spina bifida and can be easily obtained during the routine first-trimester scan. |
Databáze: | OpenAIRE |
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