Synthesis of novel β-aminocyclobutanecarboxylic acid derivatives by a solvent-free aza-Michael addition and subsequent ring closure
| Autor: | Tamara Meiresonne, Sven Mangelinckx, Norbert De Kimpe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Stereochemistry
2-AMINOCYCLOBUTANECARBOXYLIC ACID Imine Carboxylic Acids Ring (chemistry) Biochemistry Medicinal chemistry chemistry.chemical_compound FOLDAMERS Benzophenone Reactivity (chemistry) AMINO-ACIDS Physical and Theoretical Chemistry chemistry.chemical_classification Aza Compounds GAMMA-PEPTIDES Solvent free DIPEPTIDES Molecular Structure Tetrapeptide URACIL DERIVATIVES Organic Chemistry PHOTOCYCLOADDITION TRANSFORMATION Amino acid Chemistry chemistry Michael reaction TETRAPEPTIDE Cyclobutanes |
| Zdroj: | ORGANIC & BIOMOLECULAR CHEMISTRY |
| ISSN: | 1477-0520 |
| Popis: | Novel beta-aminocyclobutanecarboxylic acid derivatives were prepared via a sequential solvent-free aza-Michael addition of benzophenone imine across 3-halopropylidenemalonates and base-induced ring closure. These highly substituted cyclobutanedicarboxylic acid derivatives were subjected to a reactivity study which demonstrated the tendency of these donor-acceptor substituted four-membered rings to be converted into their corresponding ring-opened products. |
| Databáze: | OpenAIRE |
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