Ferric Ammonium Citrate as a Positive Bowel Contrast Agent for MR Imaging of the Upper Abdomen
| Autor: | Matthias Taupitz, K. P. Lodemann, T. Krahe, Dietmar Kivelitz, H.-B. Gehl, A. Heuck, Bernd Hamm |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Gastrointestinal Diseases Administration Oral Contrast Media Distension Ferric Compounds law.invention Double-Blind Method Randomized controlled trial law Oral administration Abdomen medicine Humans Radiology Nuclear Medicine and imaging Adverse effect Aged Aged 80 and over Observer Variation Radiological and Ultrasound Technology business.industry Reproducibility of Results General Medicine Middle Aged Magnetic Resonance Imaging Effective dose (pharmacology) Quaternary Ammonium Compounds Clinical trial medicine.anatomical_structure Ferric Female Safety Artifacts business Nuclear medicine Digestive System medicine.drug |
| Zdroj: | Acta Radiologica. 40:429-435 |
| ISSN: | 1600-0455 0284-1851 |
| DOI: | 10.3109/02841859909177759 |
| Popis: | Purpose: To evaluate the safety and diagnostic efficacy of two different doses of ferric ammonium citrate as a paramagnetic oral contrast agent for MR imaging of the upper abdomen. Material and Methods: Ninety-nine adult patients referred for MR imaging for a known or suspected upper abdominal pathology were included in this randomized multicenter double-blind clinical trial. Imaging was performed with spin-echo (T1- and T2-weighted) and gradient-echo (T1-weighted) techniques before and after administration of either 1200 mg or 2400 mg of ferric ammonium citrate dissolved in 600 ml of water. Safety analysis included monitoring of vital signs, assessment of adverse events, and laboratory testing. Efficacy with regard to organ distension, contrast distribution, bowel enhancement and delineation of adjacent structures was graded qualitatively. Results: No serious adverse events were reported for either of the two concentrations. A total of 31 minor side effects were noted, of which significantly more occurred in the higher dose group ( p Conclusion: Ferric ammonium citrate is a safe and effective oral contrast agent for MR imaging of the upper abdomen at two different dose levels. The higher dose showed a tendency toward better imaging results while the lower dose caused significantly fewer side effects. Therefore the 1200 mg dose can be recommended in view of the risk-to-benefit ratio. |
| Databáze: | OpenAIRE |
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