Accuracy of potential diagnostic indicators for coeliac disease: a systematic review protocol
| Autor: | Hayley E Jones, Hazel Everitt, Penny Whiting, Jo Stubbs, Joni Jackson, Alastair D Hay, Howard Thom, Gerry Robins, Jessica Watson, Peter M. Gillett, Sarah Dawson, Martha M C Elwenspoek, Deborah L. Lane, Susan Mallett, Athena L. Sheppard |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Referral diagnosis MEDLINE Gastroenterology and Hepatology Cochrane Library Sensitivity and Specificity Coeliac disease Meta-Analysis as Topic Quality of life Biopsy medicine HEB risk factors Humans Mass Screening Child Intensive care medicine Protocol (science) medicine.diagnostic_test business.industry General Medicine medicine.disease Celiac Disease Data extraction Research Design Quality of Life symptoms Medicine systematic review protocol business coeliac disease Systematic Reviews as Topic |
| Zdroj: | BMJ Open, Vol 10, Iss 10 (2020) BMJ Open Elwenspoek, M M C, Jackson, J, Dawson, S, Everitt, H, Gillet, P, Hay, A D, Jones, H E, Lane, D, Mallett, S, Robins, G, Sheppard, A, Stubbs, J, Thom, H H Z, Watson, J C & Whiting, P F 2020, ' Accuracy of potential diagnostic indicators for coeliac disease : a systematic review protocol ', BMJ Open, vol. 10, no. 10, e038994 . https://doi.org/10.1136/bmjopen-2020-038994 |
| ISSN: | 2044-6055 |
| Popis: | Introduction Coeliac disease (CD) is a systemic immune-mediated disorder triggered by gluten in genetically predisposed individuals. CD is diagnosed using a combination of serology tests and endoscopic biopsy of the small intestine. However, because of non-specific symptoms and heterogeneous clinical presentation, diagnosing CD is challenging. Early detection of CD through improved case-finding strategies can improve the response to a gluten-free diet, patients’ quality of life and potentially reduce the risk of complications. However, there is a lack of consensus in which groups may benefit from active case-finding.Methods and analysis We will perform a systematic review to determine the accuracy of diagnostic indicators (such as symptoms and risk factors) for CD in adults and children, and thus can help identify patients who should be offered CD testing. MEDLINE, Embase, Cochrane Library and Web of Science will be searched from 1997 until 2020. Screening will be performed in duplicate. Data extraction will be performed by one and checked by a second reviewer. Disagreements will be resolved through discussion or referral to a third reviewer. We will produce a narrative summary of identified prediction models. Studies, where 2×2 data can be extracted or reconstructed, will be treated as diagnostic accuracy studies, that is, the diagnostic indicators are the index tests and CD serology and/or biopsy is the reference standard. For each diagnostic indicator, we will perform a bivariate random-effects meta-analysis of the sensitivity and specificity.Ethics and dissemination Results will be reported in peer-reviewed journals, academic and public presentations and social media. We will convene an implementation panel to advise on the optimum strategy for enhanced dissemination. We will discuss findings with Coeliac UK to help with dissemination to patients. Ethical approval is not applicable, as this is a systematic review and no research participants will be involved.PROSPERO registration number CRD42020170766.https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.http://dx.doi.org/10.1136/bmjopen-2020-038994 |
| Databáze: | OpenAIRE |
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