Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription
| Autor: | L I, Zon, Y, Yamaguchi, K, Yee, E A, Albee, A, Kimura, J C, Bennett, S H, Orkin, S J, Ackerman |
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| Rok vydání: | 1993 |
| Předmět: |
Transcription
Genetic Molecular Sequence Data Immunology Gene Expression GATA3 Transcription Factor Biochemistry Cell Line Humans GATA1 Transcription Factor RNA Messenger Base Sequence Cell Biology Hematology Blotting Northern Basophils DNA-Binding Proteins Eosinophils GATA2 Transcription Factor Butyrates embryonic structures Trans-Activators Butyric Acid Erythroid-Specific DNA-Binding Factors Interleukin-5 HeLa Cells Transcription Factors |
| Zdroj: | Blood. 81:3234-3241 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v81.12.3234.bloodjournal81123234 |
| Popis: | The expression of the hematopoietic transcription factors GATA-1, GATA- 2, and GATA-3 was studied in eosinophils and basophils. Eosinophils express mRNA for GATA-1, GATA-2, and GATA-3. Basophils express GATA-2 and GATA-3. Treatment of HL-60 eosinophilic sublines with either interleukin-5 or butyric acid increased the expression of GATA-1 mRNA concomitant with the expression of eosinophil-specific genes, whereas levels of GATA-2 mRNA remained relatively constant. The presence of mRNA for these proteins in eosinophils and basophils suggests that gene transcription in these lineages may be regulated by GATA-binding proteins. |
| Databáze: | OpenAIRE |
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