The immunogenicity and protection effect of an inactivated coxsackievirus A6, A10, and A16 vaccine against hand, foot, and mouth disease
Autor: | Heeji Lim, Sang-Won Lee, Jung-Ah Lee, June-Woo Lee, Hyun Ju In, Gyung Tae Chung, Jae Keun Chung, Sun Ju Cho, Young Ki Choi, Jung Sik Yoo |
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Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Cross Protection Coxsackievirus medicine.disease_cause Antibodies Viral 03 medical and health sciences Interferon-gamma Mice Immune system Immunogenicity Vaccine stomatognathic system Neutralization Tests Formaldehyde Propiolactone medicine Enterovirus 71 Animals Humans Neutralizing antibody Vaccine Potency Immunity Cellular Mice Inbred BALB C General Veterinary General Immunology and Microbiology biology business.industry Immunogenicity Public Health Environmental and Occupational Health Outbreak Viral Vaccines biology.organism_classification Virology Antibodies Neutralizing Survival Analysis Enterovirus A Human 030104 developmental biology Infectious Diseases Vaccines Inactivated Inactivated vaccine Vaccines Subunit biology.protein Molecular Medicine Enterovirus Female business Hand Foot and Mouth Disease |
Zdroj: | Vaccine. 36(24) |
ISSN: | 1873-2518 |
Popis: | Coxsackievirus belongs to the Enterovirus genus of the Picornaviridae family and is one of the major pathogens associated with human hand, foot, and mouth disease (HFMD). Historically, outbreaks of HFMD have mainly been caused by enterovirus 71 and coxsackievirus A16. Recently, coxsackieviruses A6 and A10 have been associated with increased occurrences of sporadic HFMD cases and outbreak events globally. In this study, the immunogenicity of coxsackieviruses A6, A10, and A16 (CA6, CA10, and CA16), which were inactivated by formalin or β-propiolactone (BPL) under different conditions, was evaluated as multivalent vaccine candidates. CA6 induced similar immune responses with both inactivation methods, and the immune efficacy of CA10 and CA16 was better following inactivation with BPL than with formalin. There was no sufficient cross-reactivity or cross-protectivity against heterologous strains in groups vaccinated with the BPL-inactivated (BI) monovalent vaccine. Sufficient neutralizing antibody and cell-mediated immune responses were induced in the BI-trivalent vaccinated group. These findings suggest that BI-CA6, CA10, and CA16 are potential multivalent vaccine candidates and that a multivalent vaccine is needed to control HFMD. The coxsackievirus multivalent vaccine could be useful for the development of effective HFMD vaccines. |
Databáze: | OpenAIRE |
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