Rice varietal differences in bioactive bran components for inhibition of colorectal cancer cell growth
| Autor: | Genevieve M. Forster, Sushil Kumar, Anna M. McClung, Komal Raina, Elizabeth P. Ryan, Ming-Hsuan Chen, Rajesh Agarwal, John E. Bauer, Ajay Kumar |
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| Rok vydání: | 2013 |
| Předmět: |
Dietary Fiber
Cell Survival Colorectal cancer medicine.medical_treatment Biology Article Analytical Chemistry chemistry.chemical_compound Phenols medicine Humans Vitamin E Cell Proliferation Bran Plant Extracts Cell growth Extramural food and beverages Oryza General Medicine medicine.disease Differential effects Growth Inhibitors Biochemistry chemistry Lipid content Growth inhibition Colorectal Neoplasms Food Science |
| Zdroj: | Food Chemistry. 141:1545-1552 |
| ISSN: | 0308-8146 |
| DOI: | 10.1016/j.foodchem.2013.04.020 |
| Popis: | Rice bran chemical profiles differ across rice varieties and have not yet been analysed for differential chemopreventive bioactivity. A diverse panel of seven rice bran varieties was analysed for growth inhibition of human colorectal cancer (CRC) cells. Inhibition varied from 0% to 99%, depending on the variety of bran used. Across varieties, total lipid content ranged 5-16%, individual fatty acids had 1.4- to 1.9-fold differences, vitamin E isoforms (α-, γ-, δ-tocotrienols, and tocopherols) showed 1.3- to 15.2-fold differences, and differences in γ-oryzanol and total phenolics ranged between 100-275ng/mg and 57-146ngGAE/mg, respectively. Spearman correlation analysis was used to identify bioactive compounds implicated in CRC cell growth inhibitory activity. Total phenolics and γ-tocotrienol were positively correlated with reduced CRC cell growth (p |
| Databáze: | OpenAIRE |
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