Raised homocystein plasma concentration in patients with Heart Failure: clinical significance
| Autor: | L. Dei Cas, Enrico Vizzardi, M. Metra, Savina Nodari, Claudia Fiorina |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Hyperhomocysteinemia Homocysteine Cardiomyopathy lcsh:Medicine chemistry.chemical_compound Internal medicine medicine Humans Risk factor Aged Heart Failure Creatinine Ejection fraction lcsh:R Dilated cardiomyopathy Middle Aged medicine.disease chemistry Heart failure Cardiology Female Cardiology and Cardiovascular Medicine |
| Zdroj: | Monaldi Archives for Chest Disease, Vol 68, Iss 2 (2016) |
| ISSN: | 2532-5264 1122-0643 |
| Popis: | Elevated plasma levels of homocysteine is associated with increased risk of thrombotic and atherosclerotic vascular disease. Several studies have demonstrated that hyperhomocysteinemia is an indipendent risk factor for vascular disease and is associated to heart failure. However there are no data regarding the association between homocysteine and various objective as well as subjective measures of heart failure. We hypothesized that plasma homocysteine is associated with clinical and echocardiographic signs of heart failure. On this ground we have analysed levels of homocysteine in patients with heart failure and possible correlation between these levels and clinical-functional pattern (NYHA class and ejection fraction). Methods: Plasma homocysteine levels were determined in 123 patients with dilated cardiomyopathy (59 males, 64 females, mean age 67±10 years, mean EF 31±11% and mean NYHA 2.4±0.9, 47 idiopatic and 76 postischemic cardiomyopathy) and 85 healthy control subjects (homogeneus group for sex and age). Patients with chronic renal failure, vitamin B12 and folate deficiency or factors affecting homocysteine plasma levels were escluded from this study. Homocysteine levels were determined in coded plasma samples by immunoenzimatic methods. Results: Patients with heart failure had a higher homocysteine level (mcg/L) than control subjects (21.72±10.28 vs 12.9±6.86, p |
| Databáze: | OpenAIRE |
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