Effect of amiloride and spironolactone on renal tubular function, ambulatory blood pressure, and pulse wave velocity in healthy participants in a double-blinded, randomized, placebo-controlled, crossover trial
| Autor: | Søren Nielsen, Henrik Vase, Thomas Larsen, Thomas G. Lauridsen, Karen Marie Nykjær, Pia Holland Gjørup, Solveig Klok Matthesen, Erling B. Pedersen |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Ambulatory blood pressure Adolescent Physiology Renal function Blood Pressure Pulse Wave Analysis Spironolactone urologic and male genital diseases Amiloride Renin-Angiotensin System chemistry.chemical_compound Double-Blind Method Internal medicine Renin–angiotensin system Internal Medicine medicine Humans Diuretics Epithelial Sodium Channels Aquaporin 2 Cross-Over Studies business.industry urogenital system Furosemide General Medicine Blood Pressure Monitoring Ambulatory Crossover study Kidney Tubules Blood pressure Endocrinology chemistry Female business Algorithms Biomarkers Glomerular Filtration Rate medicine.drug |
| Zdroj: | Matthesen, S K, Larsen, T, Lauridsen, T G, Vase, H, Gjørup, P H, Nykjær, K M, Nielsen, S & Pedersen, E B 2012, ' Effect of amiloride and spironolactone on renal tubular function, ambulatory blood pressure, and pulse wave velocity in healthy participants in a double-blinded, randomized, placebo-controlled, crossover trial ', Clinical and Experimental Hypertension, vol. 34, no. 8, pp. 588-600 . https://doi.org/10.3109/10641963.2012.681730 |
| Popis: | We wanted to test the hypothesis that treatment with amiloride or spironolactone reduced ambulatory (ABP) and central blood pressure (CBP) and that tubular transport via ENaCγ and AQP2 was increased after furosemide treatment. During baseline conditions, there were no differences in ABP, CBP, renal tubular function, or plasma concentrations of vasoactive hormones. After furosemide treatment, an increase in CBP, CH(2)o, FE(Na), FE(K), u-AQP2/min, u-ENaCγ/min, PRC, p-Ang II, and p-Aldo was observed. The increases in water and sodium absorption via AQP2 and ENaC after furosemide treatment most likely are compensatory phenomena to antagonize water and sodium depletion. |
| Databáze: | OpenAIRE |
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