Cell stemness, epithelial-to-mesenchymal transition, and immunoevasion: Intertwined aspects in cancer metastasis
| Autor: | Paolo D'Arrigo, Vincenza Vigorito, Maria Fiammetta Romano, Simona Romano, Salvatore Russo, Martina Tufano |
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| Přispěvatelé: | Romano, Simona, Tufano, M, D'Arrigo, P, Vigorito, V, Russo, S, Romano, Mf |
| Rok vydání: | 2020 |
| Předmět: |
PD-L1
0301 basic medicine Cancer Research Epithelial-Mesenchymal Transition medicine.medical_treatment Cell B7-H1 Antigen 03 medical and health sciences 0302 clinical medicine Immune system Cancer immunotherapy Neoplasms Tumor Microenvironment medicine Humans Epithelial–mesenchymal transition Neoplasm Metastasis Cell Death biology Mesenchymal phenotype Mesenchymal stem cell Cancer medicine.disease Killer Cells Natural 030104 developmental biology medicine.anatomical_structure Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer stemne Cancer cell Disease Progression Neoplastic Stem Cells biology.protein Cancer research Immunoevasion Tumor Escape Disease Susceptibility |
| Zdroj: | Seminars in Cancer Biology. 60:181-190 |
| ISSN: | 1044-579X |
| DOI: | 10.1016/j.semcancer.2019.08.015 |
| Popis: | Recent advances in tumor immunology, fostered by dramatic outcomes with cancer immunotherapy, have opened new scenarios in cancer metastasis. The cancer stemness/mesenchymal phenotype and an excess of immune suppressive signals are emerging as Intertwined aspects of human tumors. This review examines recent studies that explored the mechanistic links between cancer cell stemness and immunoevasion, and the evidence points to these key events in cancer metastasis as two sides of the same coin. This review also covers the mechanisms involved in tumor expression of programmed cell death ligand 1 (PD-L1), a major factor exploited by human neoplasias to suppress immune control. We highlight the convergence of mesenchymal traits and PD-L1 expression and examine the functions of this immune inhibitory molecule, which confers cancer cell resistance and aggressiveness. |
| Databáze: | OpenAIRE |
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