Angiotensin IV improves spatial memory in streptozotocin-induced diabetic rats by reducing oxidative stress and altering BDNF levels
| Autor: | Ismail Meral, Huri Bulut, Savas Ustunova, Gulderen Sahin, Birsen Elibol, Aysu Kilic |
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| Přispěvatelé: | İstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Bulut, Huri, ELİBOL, BİRSEN |
| Rok vydání: | 2021 |
| Předmět: |
System
0301 basic medicine medicine.medical_specialty cognitive functions hippocampus Neurotrophic Factor Morris water navigation task Hippocampal formation medicine.disease_cause Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Diabetes mellitus medicine oxidative stress KILIÇ A. ÜSTÜNOVA S. ELİBOL B. Bulut H. MERAL İ. Sahin G. -Angiotensin IV improves spatial memory in streptozotocin-induced diabetic rats by reducing oxidative stress and altering BDNF levels- ACTA NEUROBIOLOGIAE EXPERIMENTALIS cilt.81 sa.2 ss.161-171 2021 angiotensin IV chemistry.chemical_classification biology Mellitus General Neuroscience Glutathione peroxidase Brain At(4) Receptor General Medicine Streptozotocin Malondialdehyde medicine.disease Benefits Angiotensin IV 030104 developmental biology Endocrinology chemistry diabetes mellitus biology.protein Cognitive Functions Behavioral Sciences hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Oxidative stress medicine.drug |
| Zdroj: | Acta Neurobiologiae Experimentalis. 81:1-11 |
| ISSN: | 1689-0035 0065-1400 |
| DOI: | 10.21307/ane-2021-015 |
| Popis: | In this study, we investigated the protective effects of angiotensin IV (Mg IV) on cognitive function in streptozotocin (STZ)-induced diabetic rats. Male Wistar albino rats, were randomly divided into four groups; control (C), diabetes (Dia, 60 mg/kg, STZ, i.p.), Mg IV (5 mu g/kg, s.c.) and Dia+Ang W. The passive avoidance and Morris water maze (MWM) tests were used to evaluate learning and memory performance. Behavioral tests were carried out between 21 and 30 days after the initial Ang IV injection. Hippocampi were dissected and retained for biochemical and Western blot analysis. The Dia group exhibited the poorest behavioral results, while the Dia+Ang W group performed highest on the MWM task. Superoxide dismutase, glutathione peroxidase, and malondialdehyde levels increased significantly in the Dia group compared to Dia+Ang IV. Brain-derived neurotrophic factor (BDNF) and N-methyl-D-aspartate levels were significantly elevated, while levels of GABA(A) significantly decreased, in the Dia+Ang IV group compared to the Dia group. These findings suggest that peripheral administration of Ang IV ameliorated spatial memory in diabetic rats by decreasing hippocampal oxidative stress and BDNF levels. Research Fund of Istanbul University Cerrahpasa Medical Faculty [33339] This work was supported by the Research Fund of Istanbul University Cerrahpasa Medical Faculty (grant number: 33339). |
| Databáze: | OpenAIRE |
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